Flexible design of ionic liquids for membrane interactions

Flexible design of ionic liquids for membrane interactions In the last years, ionic liquids gained a lot of interest in materials sciences. Especially their interactions with biomolecules like lipids or proteins became more and more fascinating. One substance class of ionic liquids are imidazolium salts, which are usually known as the precursors of the more prominent N-heterocyclic carbenes (NHCs). Due to their high stability and easy synthesis, imidazolium salts became more attractive for applications in biological systems. In 2015, imidazolium salts bearing long alkyl chains in their backbone were established as lipid analogs. Interestingly, different effects of the intercalation into a membrane can be observed depending on the characteristics of the structure. Within this tutorial, we would like to highlight the modular synthesis of these compounds leading to a versatile tool box of lipid analogs that can be adjusted depending on the required needs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biophysical Reviews Springer Journals

Flexible design of ionic liquids for membrane interactions

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Life Sciences; Biochemistry, general; Biological and Medical Physics, Biophysics; Cell Biology; Membrane Biology; Biological Techniques; Nanotechnology
ISSN
1867-2450
eISSN
1867-2469
D.O.I.
10.1007/s12551-018-0412-9
Publisher site
See Article on Publisher Site

Abstract

In the last years, ionic liquids gained a lot of interest in materials sciences. Especially their interactions with biomolecules like lipids or proteins became more and more fascinating. One substance class of ionic liquids are imidazolium salts, which are usually known as the precursors of the more prominent N-heterocyclic carbenes (NHCs). Due to their high stability and easy synthesis, imidazolium salts became more attractive for applications in biological systems. In 2015, imidazolium salts bearing long alkyl chains in their backbone were established as lipid analogs. Interestingly, different effects of the intercalation into a membrane can be observed depending on the characteristics of the structure. Within this tutorial, we would like to highlight the modular synthesis of these compounds leading to a versatile tool box of lipid analogs that can be adjusted depending on the required needs.

Journal

Biophysical ReviewsSpringer Journals

Published: Mar 16, 2018

References

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