DOI 10.1007/s10600-018-2412-1 Chemistry of Natural Compounds, Vol. 54, No. 3, May, 2018 1* 2,3 E. Kh. Botirov and A. M. Karimov Plants of the genus Scutellaria L. growing in Uzbekistan were systematically studied in a search for new biologically active flavonoids and their accessible sources [1–7]. Previously, flavonoids from S. intermedia Popov were studied by us. The aerial plant part yielded chrysin, oroxylin A, 7-O-methylnorwogonin, 5,7,2-trihydroxyflavone, scutevulin, 2(S)-5,7,2- trihydroxyflavanone, baicalein, apigenin, chrysin 7-O--D-glucuronide, wogonin 7-O--D-glucuronide, baicalein 7-O--D- glucuronide (baicalin), 5,7,2-trihydroxyflavone 2-O--D-glucuronopyranoside, and scutevulin 2-O--D-glucuronopyranoside [6, 7]. Herein, flavonoids from roots of this species collected (November 2016) in the foothills of Pap District, Republic of Uzbekistan, during dieback of the aerial part are reported. Air-dried ground roots (567 g) were extracted (5) with EtOH (80%) at room temperature. The resulting extract was condensed by vacuum evaporation, diluted with H O, and extracted sequentially with petroleum ether, EtOAc, and n-BuOH. The solvents were distilled off to produce EtOAc (24.8 g) and n-BuOH fractions (32.5 g). Part (23.0 g) of the EtOAc fraction was chromatographed over a column of silica gel (660 g) using a petroleum ether–EtOAc gradient (60:400:100). The resulting subfractions were chromatographed over columns of silica gel and Sephadex LH-20
Chemistry of Natural Compounds – Springer Journals
Published: Jun 7, 2018
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