Adv Ther (2017) 34:1976–1988 DOI 10.1007/s12325-017-0584-x ORIGINAL RESEARCH Fixed-Dose Versus Off-Label Combination of Isosorbide Dinitrate Plus Hydralazine Hydrochloride: Retrospective Propensity-Matched Analysis in Black Medicare Patients with Heart Failure . . . . Elizabeth Oﬁli Inder Anand Richard Allen Williams Ola Akinboboye Liou Xu Gary Puckrein Received: May 19, 2017 / Published online: July 13, 2017 The Author(s) 2017. This article is an open access publication without any supporting outcome data. We ABSTRACT conducted an exploratory retrospective propensity-matched cohort study using Medi- Introduction: Based upon the ﬁndings of the care data to determine whether a survival dif- African-American Heart Failure Trial, the US ference exists between these treatments in Food and Drug Administration approved the medication-adherent patients. ﬁxed-dose combination of isosorbide dinitrate Methods: Black Medicare beneﬁciaries with HF (ISDN) and hydralazine hydrochloride (HYD) were matched with Medicare Part D data to (FDC-ISDN/HYD) as a new drug for treatment of identify patients with prescriptions to heart failure (HF) in self-identiﬁed African FDC-ISDN/HYD or the off-label combinations. Americans. According to the FDA, FDC-ISDN/ Only patients with 1-year adherence levels HYD has no therapeutic equivalent. However, C80% were included in the analysis. Propen- off-label combinations of the separate generic sity-matched scoring created two
Advances in Therapy – Springer Journals
Published: Jul 13, 2017
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