Cardiovasc Intervent Radiol (2018) 41:1611–1617 https://doi.org/10.1007/s00270-018-2003-3 LABORATORY INVESTIGATION First In Vivo Test of Thermoembolization: Turning Tissue Against Itself Using Transcatheter Chemistry in a Porcine Model 1 1 Erik N. K. Cressman Chunxiao Guo Received: 2 February 2018 / Accepted: 26 May 2018 / Published online: 5 June 2018 Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2018 Abstract indicating recanalization had not occurred. Histology Purpose Embolotherapies are commonly used for man- specimens demonstrated coagulative necrosis centered on agement of primary liver cancer. Explant studies of treated the vessel lumen extending for several hundred microns livers, however, reveal an untreated tumor in a high frac- with a peripheral inﬂammatory inﬁltrate. tion of cases. To improve on this, we propose a new con- Conclusions Thermoembolization is a new technique for cept referred to as thermoembolization. In this technique, embolization with initial promise. However, results indi- the embolic material reacts in local tissues. Highly local- cate much work must be done to optimize the technique. ized heat energy is released simultaneously with the gen- eration of acid in the target vascular bed. Combined with Keywords Embolization Hepatocellular carcinoma ischemia, this should
CardioVascular and Interventional Radiology – Springer Journals
Published: Jun 5, 2018
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