Fine-mapping and construction of a bovine contig spanning the ovine callipyge locus

Fine-mapping and construction of a bovine contig spanning the ovine callipyge locus The callipyge (CLPG) gene was fine-mapped by linkage analysis to a 4.6-cM chromosome interval on distal ovine OAR18q, flanked by microsatellite markers IDVGA30 and OY3. The OAR18q linkage map and human HSA14q transcript map were aligned by genotyping two bovine-hamster whole-genome radiation hybrid panels with the microsatellite markers, as well as with sequences corresponding to HSA14q genes. Using Type I loci mapping to the IDVGA30–OY3 interval as anchor points, we have constructed a 1.4-Mb bovine BAC contig containing the IDVGA30–OY3 interval. We demonstrate that the IDVGA30– OY3 interval spans approximately 770 kb and contains at least four genes: YY1, WARS, DLK1, and GTL2. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Fine-mapping and construction of a bovine contig spanning the ovine callipyge locus

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Publisher
Springer-Verlag
Copyright
Copyright © 2001 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003350010248
Publisher site
See Article on Publisher Site

Abstract

The callipyge (CLPG) gene was fine-mapped by linkage analysis to a 4.6-cM chromosome interval on distal ovine OAR18q, flanked by microsatellite markers IDVGA30 and OY3. The OAR18q linkage map and human HSA14q transcript map were aligned by genotyping two bovine-hamster whole-genome radiation hybrid panels with the microsatellite markers, as well as with sequences corresponding to HSA14q genes. Using Type I loci mapping to the IDVGA30–OY3 interval as anchor points, we have constructed a 1.4-Mb bovine BAC contig containing the IDVGA30–OY3 interval. We demonstrate that the IDVGA30– OY3 interval spans approximately 770 kb and contains at least four genes: YY1, WARS, DLK1, and GTL2.

Journal

Mammalian GenomeSpringer Journals

Published: Feb 1, 2001

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