Mouse Resources FIMRe: Federation of International Mouse Resources: Global Networking of Resource Centers FIMRe Board of Directors The Jackson Laboratory, 600 Main St., Bar Harbor, Maine 04609, USA Received: 4 January 2006 / Accepted: 30 January 2006 It is widely accepted that the mouse is the best ge- existing strains. The magnitude and challenge of netic model for studying human biology and disease. maintaining and distributing mutant ES cell lines This is primarily because of the staggering array of and mouse strains rapidly and economically to inbred mouse strains, transgenics, knockouts, and individual researchers requires new strategic ap- spontaneous mutants with highly defined genetic proaches to succeed, as well as partnerships between backgrounds. Furthermore, the existence of large mouse repositories and the researchers who are numbers of strain-specific genetic markers makes generating, archiving, and phenotyping the mice. the mouse an obvious tool for the mapping and Major mouse repositories currently exist in identification of novel genes and their alleles. Europe, Asia, and North America, accounting for When the large-scale mutagenesis programs be- nearly 10,000 mouse strains either live or as cryop- gan in the last decade, thousands of mouse strains reserved embryos, ovaries, or sperm. This is in already
Mammalian Genome – Springer Journals
Published: Jan 1, 2006
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