Fertility preservation: ovarian response to freeze oocytes is not affected by different malignant diseases—an analysis of 992 stimulations

Fertility preservation: ovarian response to freeze oocytes is not affected by different malignant... Purpose To study if ovarian response is affected by the type of disease if fertility preservation is required. Methods A registry of the trinational fertility preservation network FertiPROTEKT including 992 patients aged 18–40 years undergoing ovarian stimulation and follicle aspiration for fertility preservation from 1/2007 until 3/2016 was analysed. The number of collected oocytes, days of stimulation, total gonadotropin dosage and gonadotropin dosage per day were evaluated. Results Total oocyte number was negatively correlated with increasing age (r =0.237, p < 0.0001). Oocyte numbers were in women < 26 years 15.4 ± 8.8, 26–30 years 13.1 ± 8.5, 31–35 years 12.2 ± 7.7 and 36–40 years 9.9 ± 8.0. Age-adjusted oocyte numbers were not different in women with Hodgkin’s lymphoma (12.6 ± 8.8), non-Hodgkin’s lymphoma (12.4 ± 8.2), leukaemia (11.7 ± 8.2), sarcoma (11.8 ± 8.2), cerebral cancer (16.5 ± 8.1), gastrointestinal cancer (13.2 ± 8.1) gynaecological cancer (10.8 ± 8.2) and other types of malignancies (15.8 ± 8.1) apart from ovarian cancer with lower oocyte yield (7.3 ± 8.3, p < 0.001) compared to women with breast cancer (13.3 ± 8.8). The total gonadotropin dose used for stimulation was only elevated in Hodgkin’s and non-Hodgkin’s lymphoma compared to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Assisted Reproduction and Genetics Springer Journals

Fertility preservation: ovarian response to freeze oocytes is not affected by different malignant diseases—an analysis of 992 stimulations

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Gynecology; Reproductive Medicine; Human Genetics
ISSN
1058-0468
eISSN
1573-7330
D.O.I.
10.1007/s10815-018-1227-0
Publisher site
See Article on Publisher Site

Abstract

Purpose To study if ovarian response is affected by the type of disease if fertility preservation is required. Methods A registry of the trinational fertility preservation network FertiPROTEKT including 992 patients aged 18–40 years undergoing ovarian stimulation and follicle aspiration for fertility preservation from 1/2007 until 3/2016 was analysed. The number of collected oocytes, days of stimulation, total gonadotropin dosage and gonadotropin dosage per day were evaluated. Results Total oocyte number was negatively correlated with increasing age (r =0.237, p < 0.0001). Oocyte numbers were in women < 26 years 15.4 ± 8.8, 26–30 years 13.1 ± 8.5, 31–35 years 12.2 ± 7.7 and 36–40 years 9.9 ± 8.0. Age-adjusted oocyte numbers were not different in women with Hodgkin’s lymphoma (12.6 ± 8.8), non-Hodgkin’s lymphoma (12.4 ± 8.2), leukaemia (11.7 ± 8.2), sarcoma (11.8 ± 8.2), cerebral cancer (16.5 ± 8.1), gastrointestinal cancer (13.2 ± 8.1) gynaecological cancer (10.8 ± 8.2) and other types of malignancies (15.8 ± 8.1) apart from ovarian cancer with lower oocyte yield (7.3 ± 8.3, p < 0.001) compared to women with breast cancer (13.3 ± 8.8). The total gonadotropin dose used for stimulation was only elevated in Hodgkin’s and non-Hodgkin’s lymphoma compared to

Journal

Journal of Assisted Reproduction and GeneticsSpringer Journals

Published: Jun 5, 2018

References

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