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RE Coleman (2006)
Clinical features of metastatic bone disease and risk of skeletal morbidityClin Cancer Res, 12
I Cieszykowska, M Zóltowska, M Mielcarski (2014)
Separation of Ytterbium from 177Lu/Yb mixture by electrolytic reduction and amalgamationSOP Trans Appl Chem, 1
B Liberman, D Gianfelice, Y Inbar (2009)
Pain palliation in patients with bone metastases using MR-guided focused ultrasound surgery: a multicenter studyAnn Surg Oncol, 16
JA Campa, R Rayne (1992)
The management of intractable bone pain: a clinician’s perspectiveSemin Nucl Med, 22
R Firestone (1996)
Table of isotopes (Shirley VS ed)
VJ Lewington (1993)
Targeted radionuclide therapy for bone metastasesEur J Nucl Med, 20
N Morcos, M Zaw, P Pellegrini (2008)
Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation. Part II. The conventional column chromatographic separation combined with HPLC for high purityJ Radioanal Nucl Chem, 277
S Banerjee, S Chakraborty, T Das (2005)
177Lu-DOTMP, 153Sm-DOTMP, 175Yb-EDTMP and 186/188Re-CTMP: novel agents for bone pain palliation and their comparison with 153Sm-EDTMPBARC Newslett., 261
N Ayati, K Aryana, A Jalilian (2013)
Treatment efficacy of 153Sm-EDTMP for painful bone metastasisAsia Ocean J Nucl Med Biol, 1
K Kumrić, T Trtić-Petrović, E Koumarianou (2006)
Supported liquid membrane extraction of 177Lu(III) with DEHPA and its application for purification of 177Lu-DOTA-lanreotideSep Purif Technol, 51
S Zolghadri, H Yousefnia, AR Jalilian (2015)
Production, biodistribution assessment and dosimetric evaluation of 177Lu-TTHMP as an agent for bone pain palliationAsia Oceania J Nucl Med Biol, 3
OJ Degrossi, P Oliveri, DRH García (1985)
Technetium-99m APD compared with technetium-99m MDP as a bone scanning agentJ Nucl Med, 26
R Chakravarty, T Das, A Dash, M Venkatesh (2010)
An electro-amalgamation approach to isolate no-carrier-added 177Lu from neutron irradiated 177Yb for biomedical applicationsNucl Med Biol, 37
CL Ligny, WJ Gelsema, TG Tji, YM Huigen (1990)
Bone seeking radiopharmaceuticalsNucl Med Biol, 17
GR Choppin, RJ Silva (1956)
Separation of the lanthanides by ion exchange with alpha-hydroxy isobutyric acidJ Inorg Nucl Chem, 3
S Ferreira, I Dormehl, MF Botelho (2012)
Radiopharmaceuticals for bone metastasis therapy and beyond: a voyage from the past to the present and a look to the futureCancer Biother Radiopharm, 27
M Marhol (1982)
Ion exchangers in analytical chemistry: their properties and use in inorganic chemistryCompr Anal Chem, 14
L Safarzadeh, M Ghannadi-Maragheh, A Anvari, SMR Aghamiri, S Shirvani-Arani, A Bahrami-Samani (2012)
Production, radiolabeling and biodistribution studies of 175Yb-DOTMP as bone pain palliationIran J Pharm Sci, 8
JR Zeevaart, NV Jarvis, WK Louw (2001)
Metal-ion speciation in blood plasma incorporating the tetraphosphonate, N,N-dimethylenephosphonate-1-hydroxy-4-aminopropilydenediphosphonate (APDDMP), in therapeutic radiopharmaceuticalsJ Inorg Biochem, 83
S Watanabe, K Hashimoto, S Watanabe (2015)
Production of highly purified no-carrier-added 177Lu for radioimmunotherapyJ Radioanal Nucl Chem, 303
FR Knapp, S Mirzadeh, AL Beets (2005)
Production of therapeutic radioisotopes in the ORNL high flux isotope reactor (HFIR) for applications in nuclear medicine, oncologyand interventional cardiologyJ Radioanal Nucl Chem, 263
M Sohaib, M Ahmad, M Jehangir (2011)
Ethylene diamine tetramethylene phosphonic acid labeled with various β emitting radiometals: labeling optimization and animal biodistributionCancer Biother Radiopharm, 26
H Yousefnia, AR Jalilian, S Zolghadri (2015)
Development of 111In DOTMP for dosimetry of bone pain palliation agentsJ Radioanal Nucl Chem, 304
N Morcos, M Zaw, P Pellegrini (2008)
Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation. Part 1. Multi-column chromatographic process for clinically applicableJ Radioanal Nucl Chem, 277
A Bilewicz, K Żuchowska, B Bartoś (2009)
Separation of Yb as YbSO4 from 176Yb target for production of 177Lu via the 176Yb (n, γ) 177Yb→177Lu processJ Radioanal Nucl Chem, 280
J Starý (1966)
Separation of transplutonium elementsTalanta, 13
FF Knapp, KR Ambrose, AL Beets (1997)
Nuclear medicine program progress report for quarter ending December 31, 1994 (No. ORNL/TM–12909)
S Chakraborty, PR Unni, M Venkatesh, MRA Pillai (2002)
Feasibility study for production of 175Yb: a promising therapeutic radionuclideAppl Radiat Isot, 57
S Chakraborty, T Das, HD Sarma (2008)
Comparative studies of 177Lu-EDTMP and 177Lu-DOTMP as potential agents for palliative radiotherapy of bone metastasisAppl Radiat Isot, 66
FO Denzler, NA Lebedev, AF Novgorodov (1997)
Production and radiochemical separation of 147GdAppl Radiat Isotopes, 48
B Mathew, S Chakraborty, T Das, HD Sarma, S Banerjee, G Samuel, MRA Pillai (2004)
175Yb labeled polyaminophosphonates as potential agents for bone pain palliationAppl Radiat Isot, 60
T Das, S Chakraborty, PR Unni (2002)
177Lu-labeled cyclic polyaminophosphonates as potential agents for bone pain palliationAppl Radiat Isot, 57
H Park, D Kwon, Y Cha (2006)
Purification and laser isotope separation of 176Yb for medical applicationsJ Korean Phys Soc, 49
CR Hammond (2000)
Handbook of chemistry and physics 81st edition
M Tomblyn (2012)
The role of bone-seeking radionuclides in the palliative treatment of patients with painful osteoblastic skeletal metastasesCancer Control, 19
IA Abbasi (2012)
Preliminary studies on 177Lu-labeled sodium pyrophosphate (177Lu-PYP) as a potential bone-seeking radiopharmaceutical for bone pain palliationNucl Med Biol, 39
F Monroy-Guzman, FJ Barreiro, EJ Salinas (2015)
Device productionWorld J Nucl Sci Technol, 5
NA Lebedev, AF Novgorodov, R Misiak (2000)
Radiochemical separation of no-carrier-added 177Lu as produced via the 176Yb (n, γ) 177Yb→177Lu processAppl Radiat Isotopes, 53
P Anderson, R Nuñez (2007)
Samarium lexidronam (153Sm-EDTMP): skeletal radiation for osteoblastic bone metastases and osteosarcomaExpert Rev Anticancer Ther, 7
K Hashimoto, H Matsuoka, S Uchida (2003)
Production of no-carrier-added 177Lu via the 176Yb (n, γ) 177Yb→177Lu processJ Radioanal Nucl Chem, 255
A Bahrami-Samani, M Ghannadi-Maragheh, AR Jalilian (2009)
Production, quality control and biological evaluation of 153Sm-EDTMP in wild-type rodentsIran J Nucl Med, 17
P Balasubramanian (1994)
Separation of carrier-free lutetium-177 from neutron irradiated natural ytterbium targetJ Radioanal Nucl Chem, 185
M Fischer, WU Kampen (2012)
Radionuclide therapy of bone metastasesBreast Care, 7
EP Horwitz, DR McAlister, AH Bond (2005)
A process for the separation of 177Lu from neutron irradiated 176Yb targetsAppl Radiat Isot, 63
K Liepe, J Kotzerke (2007)
A comparative study of 188Re-HEDP, 186Re-HEDP, 153Sm-EDTMP and 89Sr in the treatment of painful skeletal metastasesNucl Med Commun, 28
S Lahiri, D Nayak, M Nandy (1998)
Separation of carrier free lutetium produced in proton activated ytterbium with HDEHPAppl Radiat Isotopes, 49
Skeletal uptake of β− emitters of DOTMP complexes is used for the bone pain palliation. In this study, two moderate energy β− emitters, 177Lu (T1/2 = 6.7 days, Eβmax = 497 keV) and 175Yb (T1/2 = 4.2 days, Eβmax = 480 keV), are considered as potential agents for the development of the bone-seeking radiopharmaceuticals. Since the specific activity of the radiolabelled carrier molecules should be high, the non-carrier-added (NCA) radionuclides have an effective role in nuclear medicine. Many researchers have presented the synthesis of NCA 177Lu. Among these separation techniques, extraction chromatography has been considered more capable than other methods. In this study, a new approach, in addition to production of NCA 177Lu by EXC procedure is using pure 175Yb that was usually considered as a waste material in this method but because of high radionuclidic purity of 175Yb produced by this method we used it for radiolabeling as well as NCA 177Lu. To obtain optimum conditions, some effective factors on separation of Lu/Yb by EXC were investigated. The NCA 177Lu and pure 175Yb were produced with radionuclidic purity of 99.99 and 99.97% respectively by irradiation of enriched 176Yb target in thermal neutron flux of 5 × 1013 n/cm2 s for 14 days. 177Lu-DOTMP and 175Yb-DOTMP were obtained with high radiochemical purities (> 95%) under optimized reaction conditions. Two radiolabeled complexes exhibited excellent stability at room temperature. Biodistribution studies in rats showed favorable selective skeletal uptake with rapid clearance from blood along with insignificant accumulation of activity in other non-target organs for two radiolabelled complexes.
Australasian Physical & Engineering Sciences in Medicine – Springer Journals
Published: Dec 19, 2017
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