Feasibility of swept-source OCT for active
Josep M. Caminal-Mitjana
Received: 6 October 2016 /Revised: 14 March 2017 /Accepted: 22 March 2017 / Published online: 3 May 2017
Springer-Verlag Berlin Heidelberg 2017
Purpose To assess the feasibility of swept-source optical co-
herence tomography (SS-OCT) for clinical follow-up of pa-
tients with birdshot chorioretinopathy (BC).
Methods Prospective longitudinal, observational, 12-month
case–control study in a tertiary care center. The study popula-
tion included 12 patients (24 eyes) diagnosed with BC and 21
age- and sex-matched healthy controls (42 eyes). The macular
areas in both affected and healthy eyes were prospectively
analyzed with SS-OCT at 1050 nm, using 2D 12.0-mm radial
and horizontal scans and the 3D raster scan protocol (12.0 ×
9.0 mm). Anatomical and structural abnormalities, as well as
retinal and choroidal thickness (measured automatically),
were evaluated and compared with visual field (VF) testing
and indocyanine green angiography (ICGA).
Results The most common qualitative abnormalities in the
retina were thinning/loss of architecture and outer retinal
hyperreflective foci, and in the choroid they were focal depig-
mentation, thinning/absence of Sattler’s layer, generalized
thinning, and hyperreflective foci. The most significant chang-
es in the retina from baseline to the 12-month follow-up were
decreases in intraretinal cysts, subretinal fluid, and hyaloid
thickening. In the choroid, focal depigmentation decreased
significantly, while vascular pattern loss increased.
Compared to the healthy volunteers, patients with BC had
thinner choroids and retinas at both baseline and study end.
Retinal thickness decreased significantly in BC patients over
the 12-month study period, but choroidal thickness remained
unchanged. Findings from ICGA, VF, and SS-OCT were per-
fectly correlated in most (≈ 60%) patients.
Conclusions SS-OCT is a non-invasive, rapid method of
assessing choroidal and retinal changes in patients with
birdshot disease. This technique provides a simple method
of monitoring the course of the disease that can be used to
complement conventional tests.
Optical coherence tomography
Birdshot chorioretinopathy (BC) is an uncommon posterior
uveitis characterized by multiple ovoid spots of
hypopigmentation, along with vitritis. These lesions are main-
ly located in the posterior pole, radiating from the optic nerve,
and in the mid-peripheral retina [1–3]. Retinal involvement
Each co-author meets the requirements for authorship.
* Olga Garcia-Garcia
Josep M. Caminal-Mitjana
Ophthalmology Department, University Hospital of Bellvitge,
Hospitalet de Llobregat, Barcelona, Spain
Ophthalmology Department, Hospital Universitari Bellvitge, c/ Feixa
Llarga s/n, 08907 Hospitalet Llobregat, Barcelona, Spain
Graefes Arch Clin Exp Ophthalmol (2017) 255:1493–1502