PharmacoEconomics & Outcomes News 792, p11 - 2 Dec 2017 FDA investigation decreases opioid prescribing in children An investigation by the US FDA into opioid prescribing for children after tonsillectomy and/or adenoidectomy, which lead to a black box warning in February 2013, appears to have achieved a reduction in opioid prescribing for these patients, according to findings of a study published in Pediatrics. Truven MarketScan Commercial Claims and Encounters data were used to investigate prescribing of opioid analgesics (codeine, hydrocodone, oxycodone or others) within 7 days after tonsillectomy and/or adenoidectomy in 362 992 US children with private insurance who underwent this surgery between 2010 and 2015. There was a significant reduction in the proportion of patients who received one or more prescription fills for codeine between 2010 and 2015 (–13.3 percentage points). Overall, 31.0% of patients received one or more prescription fills for codeine in January 2010 compared with 5.1% in December 2015. The FDA investigation was associated with a nonsignificant reduction in the prescribing of opioids other than codeine (–1.2 percentage points). However, other factors lead to an increase in the proportion of children receiving alternative opioids, from 31.7% in January 2010 to 46.1% in December 2015. "Future quality-improvement efforts should focus on eliminating this residual inappropriate codeine prescribing and on encouraging the use of effective nonopioid medications such as ibuprofen," said the authors. Chua KP, et al. Effect of FDA Investigation on Opioid Prescribing to Children After Tonsillectomy/Adenoidectomy. Pediatrics : 16 Nov 2017. Available from: URL: http://doi.org/10.1542/peds.2017-1765 803284957 1173-5503/17/0792-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved PharmacoEconomics & Outcomes News 2 Dec 2017 No. 792
PharmacoEconomics & Outcomes News – Springer Journals
Published: Dec 2, 2017
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