Fatty ethylhydrazide from palm oil: chemical synthesis
A. Guo Jaloob
Tee Ta Yeong
Received: 24 August 2012 / Accepted: 20 November 2012 / Published online: 1 December 2012
Ó Springer Science+Business Media Dordrecht 2012
Abstract In this study, palm oil was reacted with ethylhydrazine in hexane by a
reﬂuxing method to produce fatty ethylhydrazides (FEHs). Glycerol was produced
as a by-product. FEHs have been characterized using elemental analysis, Fourier
transform infrared spectroscopy, and
H nuclear magnetic resonance techniques.
The results showed that a 6:1 molar ratio of palm oil to ethylhydrazine, giving about
76 % maximum conversion of palm oil into FEHs, and an 11-h reaction time are the
optimum reaction conditions.
Keywords Fatty ethylhydrazide Á Palm oil Á Chemical synthesis
In addition to being useful for a number of biological properties, hydrazides and their
derivatives are important starting materials for a wide range of derivatives utilizable in
pharmaceutical products, as signiﬁcant intermediates in the synthesis polypeptide
chains, and as surfactants. Hydrazides have been known to be associated with
antibacterial , antifungal , anthelmintic , and anticonvulsant  activities.
Stefan et al.  reported that the reactions of hydrazides modiﬁed oligonucle-
otides like amines, but they have lower pka (4–5) than the pka of primary amine
(11–11). They can be used as organic reagents to determine trace metals in aqueous
solution based on the reaction of hydrazide with them, because the presence of long
chain fatty acids from palm oil (mainly 16 and 18 carbon atoms) containing O and N
atoms suggests that fatty methylhydrazides should be very useful as organic
reagents for extraction and separation of metal ions from aqueous solution [6–20].
Recently, they have also been used with other fatty nitrogen compounds as
A. G. Jaloob (&) Á T. T. Yeong
Department of Chemistry, University of Science and Technology, Hefei, China
Res Chem Intermed (2013) 39:4269–4275