Curr Surg Rep (2018) 6:12 https://doi.org/10.1007/s40137-018-0208-7 NUTRITION, METABOLISM, AND SURGERY (K. MILLER, SECTION EDITOR) 1,2,6 3 4,5 • • Carla Venegas-Borsellino Sonikpreet Neal Bhutiani Published online: 31 May 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract popular opinion, developing supportive evidence in tar- Recent Findings Each year 40,000 people are diagnosed geting their special metabolic proﬁle is promising and with primary brain tumors. Malignant gliomas account for fascinating. more than 50% of them and are universally fatal despite aggressive surgery and combined chemoradiotherapy. Keywords Glioblastoma Brain cancer Fasting Identiﬁcation of novel therapeutic targets has been chal- Ketogenic diet Caloric restriction Differential stress lenging. New areas of interest are now focusing on resistance exploiting special metabolic adaptations these tumors have developed in response to the stress caused by their rapid growth rate, exceeding their vascular supply. Introduction Purpose of Review This article is an attempt to review a controversial strategy of modulating tumor biology by Highly invasive and angiogenic glioblastomas (GBM) and understanding their metabolic characteristics, how they anaplastic astrocytomas comprise the majority of primary differ from normal healthy cells, and implementing thera- brain tumors; despite the best available treatment options pies that
Current Surgery Reports – Springer Journals
Published: May 31, 2018
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