Background Endoscopic submucosal dissection (ESD) with snaring (hybrid ESD) bridges the gap between ESD and endo- scopic mucosal resection. We evaluated factors predictive of en bloc and complete resection of large colorectal neoplasms using hybrid ESD. Methods This was a prospective clinical study of 78 patients who underwent hybrid ESD for excision of colorectal neoplasms (≥ 2 cm) between May 2015 and September 2016 at six university hospitals. We evaluated lesion and patient characteristics, endoscopist experience level (< 50 or ≥ 50 cases with colorectal ESD), and technical factors such as concurrent fibrosis, completion of a circumferential incision, degree of submucosal dissection (< 50 or ≥ 50%), and visualization during snaring (< 50 or ≥ 50%). Results Multivariate analyses showed that the en bloc resection rate was significantly related to the degree of visualization during snaring (odds ratio (OR) 7.811, 95% confidence interval [CI] 1.722–35.426; p = 0.008) and the presence of fibrosis (OR 0.258, 95% CI 0.68–0.993; p = 0.049). The complete resection rate was significantly related to the colorectal ESD endoscopist skill level (OR 5.626, 95% CI 1.485–21.313; p = 0.011) and gross lesion type (OR 0.145, 95% CI 0.022–0.936; p = 0.042). When all three technical factors,
Digestive Diseases and Sciences – Springer Journals
Published: Jun 7, 2018
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