Facile three-component preparation of benzodiazepine
derivatives catalyzed by zinc sulﬁde nanoparticles
via grinding method
Received: 15 April 2015 / Accepted: 28 August 2015 / Published online: 4 September 2015
Ó Springer Science+Business Media Dordrecht 2015
In this research, ZnS nanoparticles were prepared and applied as hetero-
geneous reusable catalyst for synthesis of 1,5-benzodiazepines under grinding conditions
at 70 °C. The multi-component reactions of aldehydes, dimedone and o-phenylenedi-
amine were carried out under grinding conditions to obtain some 3,3-dimethyl-
2,3,4,5,10,11-hexahydro-11-[aryl]-1H-dibenzo[b,e][1,4] diazepine-1-one derivatives.
The present approach provides several advantages, including high yields, short reaction
times, little catalyst loading and puriﬁcation of compounds by crystallization method.
The catalyst was characterized by using FT-IR, XRD, PL, EDX, SEM and TEM
Electronic supplementary material The onlineversion of this article (doi:10.1007/s11164-015-2254-4)
contains supplementary material, which is available to authorized users.
& Hossein Naeimi
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan 87317,
Islamic Republic of Iran
Res Chem Intermed (2016) 42:3999–4020