Res Chem Intermed (2016) 42:8097–8108 DOI 10.1007/s11164-016-2581-0 Facile one-pot green synthesis of tetrahydro- biphenylene-1,3-dicarbonitriles in aqueous media under ultrasound irradiation 1 1 • • Nhlanhla Gracious Shabalala Suresh Maddila Sreekantha B. Jonnalagadda Received: 4 February 2016 / Accepted: 16 May 2016 / Published online: 26 May 2016 Springer Science+Business Media Dordrecht 2016 Abstract An efﬁcient and rapid procedure for the synthesis of 16 novel tetrahydro- biphenylene-1,3-dicarbonitrile derivatives (4a–p) is described, employing the reaction of aromatic aldehydes, malononitrile and 3-methyl-cyclohexanone or 2-methyl-cyclohex- anone at room temperature in aqueous NaOH under ultrasonic irradiation, with excellent yields. The other attractive features of this protocol over conventional methods are the green principles, operational simplicity, easy handling, time-reducing, mild reaction conditions and no by-product production. Graphical abstract O O CH CN CN CN NH CN 2 NH CN CN CN 4a-n 4o-p CN Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2581-0) contains supplementary material, which is available to authorized users. & Sreekantha B. Jonnalagadda firstname.lastname@example.org School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South Africa 123 8098 N. G. Shabalala et al. Keywords Green synthesis One-pot synthesis 2-Amino-1,3-dicarbonitriles Functionalized aromatics Multicomponent reactions
Research on Chemical Intermediates – Springer Journals
Published: May 26, 2016
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