Facile one-pot green synthesis of tetrahydrobiphenylene-1,3-dicarbonitriles in aqueous media under ultrasound irradiation

Facile one-pot green synthesis of tetrahydrobiphenylene-1,3-dicarbonitriles in aqueous media... Res Chem Intermed (2016) 42:8097–8108 DOI 10.1007/s11164-016-2581-0 Facile one-pot green synthesis of tetrahydro- biphenylene-1,3-dicarbonitriles in aqueous media under ultrasound irradiation 1 1 • • Nhlanhla Gracious Shabalala Suresh Maddila Sreekantha B. Jonnalagadda Received: 4 February 2016 / Accepted: 16 May 2016 / Published online: 26 May 2016 Springer Science+Business Media Dordrecht 2016 Abstract An efficient and rapid procedure for the synthesis of 16 novel tetrahydro- biphenylene-1,3-dicarbonitrile derivatives (4a–p) is described, employing the reaction of aromatic aldehydes, malononitrile and 3-methyl-cyclohexanone or 2-methyl-cyclohex- anone at room temperature in aqueous NaOH under ultrasonic irradiation, with excellent yields. The other attractive features of this protocol over conventional methods are the green principles, operational simplicity, easy handling, time-reducing, mild reaction conditions and no by-product production. Graphical abstract O O CH CN CN CN NH CN 2 NH CN CN CN 4a-n 4o-p CN Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2581-0) contains supplementary material, which is available to authorized users. & Sreekantha B. Jonnalagadda jonnalagaddas@ukzn.ac.za School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South Africa 123 8098 N. G. Shabalala et al. Keywords Green synthesis  One-pot synthesis  2-Amino-1,3-dicarbonitriles Functionalized aromatics  Multicomponent reactions  http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Facile one-pot green synthesis of tetrahydrobiphenylene-1,3-dicarbonitriles in aqueous media under ultrasound irradiation

Loading next page...
Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial