Facile microwave-assisted synthesis of bis-pyrazol
pyrimidine derivatives via an N-alkylation reaction
Received: 15 January 2010 / Accepted: 5 November 2010 / Published online: 4 December 2010
Ó Springer Science+Business Media B.V. 2010
We present herein a new and efﬁcient method for synthesis of bis-pyrazol
pyrimidine derivatives by N-alkylation using a microwave-assisted synthetic process.
Two new compounds, N-(4,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)methyl nicotinonitrile and
2,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-4-methyl nicotinonitrile, were synthesized by the
N-alkylation reaction. The novel compounds were characterized by Fourier transform
infrared spectrometry, ultraviolet spectroscopy, elemental analysis, and nuclear magnetic
resonance spectroscopy, etc. The microwave-assisted procedures have noteworthy advan-
tages in terms of thermal efﬁciency over those carried out by conventional heating methods.
Keywords Microwave-assisted reactions Á Bis-pyrazol pyrimidine Á
Derivatives Á N-Alkylation
The design of novel, highly active catalysts for different processes of chemical
technology is a important topic in modern chemistry. Of great practical importance
are synthesis and study of new catalytic systems for production of organic polymers
with desired properties . Extensive investigations are being performed on the
catalytic activity of complexes of 3d transition metals with nitrogen-containing
Shi-Wen Huang and Jin-Sheng Cheng contributed equally to this study.
Electronic supplementary material The onlineversion of this article (doi:10.1007/s11164-010-0217-3)
contains supplementary material, which is available to authorized users.
S.-W. Huang Á J.-S. Cheng Á L. Qian Á S.-Y. Huang
Department of Chemistry, Youjiang Medical College for Nationalities, Baise 533000, China
J.-S. Cheng (&)
Department of Chemistry, University of Science and Technology of China, Hefei 230026, China
Res Chem Intermed (2011) 37:1–9