Facile DES-mediated synthesis and antioxidant potency of benzimidazoquinazolinone motifs

Facile DES-mediated synthesis and antioxidant potency of benzimidazoquinazolinone motifs Res Chem Intermed (2017) 43:1847–1861 DOI 10.1007/s11164-016-2734-1 Facile DES-mediated synthesis and antioxidant potency of benzimidazoquinazolinone motifs 1 2 1 • • Vilas N. Mahire Vijay E. Patel Pramod P. Mahulikar Received: 30 May 2016 / Accepted: 6 September 2016 / Published online: 16 September 2016 Springer Science+Business Media Dordrecht 2016 Abstract One-pot multicomponent synthesis of benzimidazoquinazolinone scaffolds was achieved by reaction between 2-aminobenzimidazole, aldehyde, and 1,3-cyclohexa- dione in choline chloride:glycerol as deep eutectic solvent (DES). The developed methodology offers mild and faster reaction conditions with excellent product yield. The synthesized compounds were screened for their antioxidant potency using 1,1-diphenyl-2- picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), 2,2 -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and metal chelating assay. Most of the compounds were found to exhibit good to comparable antioxidant activity with respect to standards. Use of this inexpensive and biodegradable solvent makes this methodology a greener approach compared with other methods reported in literature. Graphical Abstract Greener, one-pot multicomponent synthesis of benzimidazo- quinazolinone scaffolds using DES (ChCl:glycerol) as efficient, recyclable, and biodegradable solvent has been achieved. The synthesized compounds show good to comparable antioxidant activity compared with standards. Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2734-1) contains supplementary http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Facile DES-mediated synthesis and antioxidant potency of benzimidazoquinazolinone motifs

Loading next page...
Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial