Facile DES-mediated synthesis and antioxidant potency
of benzimidazoquinazolinone motifs
Vilas N. Mahire
Vijay E. Patel
Pramod P. Mahulikar
Received: 30 May 2016 / Accepted: 6 September 2016 / Published online: 16 September 2016
Ó Springer Science+Business Media Dordrecht 2016
One-pot multicomponent synthesis of benzimidazoquinazolinone scaffolds
was achieved by reaction between 2-aminobenzimidazole, aldehyde, and 1,3-cyclohexa-
dione in choline chloride:glycerol as deep eutectic solvent (DES). The developed
methodology offers mild and faster reaction conditions with excellent product yield. The
synthesized compounds were screened for their antioxidant potency using 1,1-diphenyl-2-
picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP),
-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and metal chelating assay.
Most of the compounds were found to exhibit good to comparable antioxidant activity with
respect to standards. Use of this inexpensive and biodegradable solvent makes this
methodology a greener approach compared with other methods reported in literature.
Greener, one-pot multicomponent synthesis of benzimidazo-
quinazolinone scaffolds using DES (ChCl:glycerol) as efﬁcient, recyclable, and
biodegradable solvent has been achieved. The synthesized compounds show good to
comparable antioxidant activity compared with standards.
Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2734-1)
contains supplementary material, which is available to authorized users.
& Pramod P. Mahulikar
School of Chemical Sciences, North Maharashtra University, Jalgaon, Maharashtra, India
School of Life Sciences, North Maharashtra University, Jalgaon, Maharashtra, India
Res Chem Intermed (2017) 43:1847–1861