Res Chem Intermed (2017) 43:1847–1861 DOI 10.1007/s11164-016-2734-1 Facile DES-mediated synthesis and antioxidant potency of benzimidazoquinazolinone motifs 1 2 1 • • Vilas N. Mahire Vijay E. Patel Pramod P. Mahulikar Received: 30 May 2016 / Accepted: 6 September 2016 / Published online: 16 September 2016 Springer Science+Business Media Dordrecht 2016 Abstract One-pot multicomponent synthesis of benzimidazoquinazolinone scaffolds was achieved by reaction between 2-aminobenzimidazole, aldehyde, and 1,3-cyclohexa- dione in choline chloride:glycerol as deep eutectic solvent (DES). The developed methodology offers mild and faster reaction conditions with excellent product yield. The synthesized compounds were screened for their antioxidant potency using 1,1-diphenyl-2- picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), 2,2 -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and metal chelating assay. Most of the compounds were found to exhibit good to comparable antioxidant activity with respect to standards. Use of this inexpensive and biodegradable solvent makes this methodology a greener approach compared with other methods reported in literature. Graphical Abstract Greener, one-pot multicomponent synthesis of benzimidazo- quinazolinone scaffolds using DES (ChCl:glycerol) as efﬁcient, recyclable, and biodegradable solvent has been achieved. The synthesized compounds show good to comparable antioxidant activity compared with standards. Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2734-1) contains supplementary
Research on Chemical Intermediates – Springer Journals
Published: Sep 16, 2016
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