Facile and efficient synthesis of benzo[b][1,5]diazepines by three-component coupling of aromatic diamines, Meldrum’s acid, and isocyanides catalyzed by Fe3O4 nanoparticles

Facile and efficient synthesis of benzo[b][1,5]diazepines by three-component coupling of aromatic... Highly effective one-pot synthesis of benzo[b][1,5]diazepines has been achieved by three-component (or, in situ, including catalyst and solvent, five-component) reaction of aromatic diamines, Meldrum’s acid, and isocyanides catalyzed by magnetite (Fe3O4) nanoparticles. Pharmaceutically and biologically active heterocyclic compounds including benzodiazepine derivatives were efficiently synthesized in excellent yields and short reaction times at room temperature. The significant features of the Fe3O4 nanoparticles are: easy preparation, cost-effectiveness, high stability, easy separation, low loading, and reusability of the catalyst. The heterogeneous nanoparticles were fully characterized by XRD, EDX, BET, SEM, TEM, and FT-IR analysis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Facile and efficient synthesis of benzo[b][1,5]diazepines by three-component coupling of aromatic diamines, Meldrum’s acid, and isocyanides catalyzed by Fe3O4 nanoparticles

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Publisher
Springer Netherlands
Copyright
Copyright © 2015 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-014-1915-z
Publisher site
See Article on Publisher Site

Abstract

Highly effective one-pot synthesis of benzo[b][1,5]diazepines has been achieved by three-component (or, in situ, including catalyst and solvent, five-component) reaction of aromatic diamines, Meldrum’s acid, and isocyanides catalyzed by magnetite (Fe3O4) nanoparticles. Pharmaceutically and biologically active heterocyclic compounds including benzodiazepine derivatives were efficiently synthesized in excellent yields and short reaction times at room temperature. The significant features of the Fe3O4 nanoparticles are: easy preparation, cost-effectiveness, high stability, easy separation, low loading, and reusability of the catalyst. The heterogeneous nanoparticles were fully characterized by XRD, EDX, BET, SEM, TEM, and FT-IR analysis.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jan 11, 2015

References

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