Fabrication of poly(ε-caprolactone) (PCL) particles with non-spherical geometries via selective dewetting and deposition of the polymer

Fabrication of poly(ε-caprolactone) (PCL) particles with non-spherical geometries via selective... This paper describes a simple, inexpensive method for the fabrication of non-spherical polymeric particles. This method involves the use of a mechanical rubbing-assisted colloidal crystal to generate a substrate with an array of dimples on its surface, followed by selectively depositing a polymer into the dimples. As a proof-of-concept experiment, we demonstrated the fabrication of poly(ε-caprolactone) (PCL) particles with non-spherical shape. The shape of the polymer particles could be controlled from disk to hemisphere by changing the surface structure and property of the substrate and the concentration of the polymer solution. When functional components including drug molecules and inorganic NPs were used together with the polymer, we could easily obtain the non-spherical particles loaded with the components. Furthermore, non-spherical particles with a hollow structure were formed with the use of immiscible polymer blend consisting of PCL and poly(ethyleneoxide) (PEO). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Colloid Polymer Science Springer Journals

Fabrication of poly(ε-caprolactone) (PCL) particles with non-spherical geometries via selective dewetting and deposition of the polymer

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Chemistry; Polymer Sciences; Soft and Granular Matter, Complex Fluids and Microfluidics; Characterization and Evaluation of Materials; Physical Chemistry; Food Science; Nanotechnology and Microengineering
ISSN
0303-402X
eISSN
1435-1536
D.O.I.
10.1007/s00396-017-4126-5
Publisher site
See Article on Publisher Site

Abstract

This paper describes a simple, inexpensive method for the fabrication of non-spherical polymeric particles. This method involves the use of a mechanical rubbing-assisted colloidal crystal to generate a substrate with an array of dimples on its surface, followed by selectively depositing a polymer into the dimples. As a proof-of-concept experiment, we demonstrated the fabrication of poly(ε-caprolactone) (PCL) particles with non-spherical shape. The shape of the polymer particles could be controlled from disk to hemisphere by changing the surface structure and property of the substrate and the concentration of the polymer solution. When functional components including drug molecules and inorganic NPs were used together with the polymer, we could easily obtain the non-spherical particles loaded with the components. Furthermore, non-spherical particles with a hollow structure were formed with the use of immiscible polymer blend consisting of PCL and poly(ethyleneoxide) (PEO).

Journal

Colloid Polymer ScienceSpringer Journals

Published: Jun 14, 2017

References

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