Eur J Plast Surg (2003) 26:276 DOI 10.1007/s00238-002-0426-0 BOOK REVIEW L. Clodius F.W. Rath, M. Schönfelder (eds): Soft Tissue Sarcomata in the Adult (Weichteilsarkome des Erwachsenen—in German), standards, molecular biology, perspectives Karger, Basel, New York, London, Singapore, Tokyo, Sidney, hard cover, 206 pp (ISBN 3-8055-7349-4) $110.00 US Published online: 19 August 2003 © Springer-Verlag 2003 This book is Vol. 56 of “Contributions to Oncology”, ed- on prognosis in these sarcomas. Under the heading “ther- ited by W. Queisser and W. Scheithauer. apy” basic principles are outlined, considering also spe- This fascinating volume on diagnosis and therapy of cific anatomical sites, e.g. the retroperitoneal space or soft tissue sarcomas is written both by well known clini- the head and neck area. The third chapter is on molecular cians and basic researchers. They combine the actual ba- biology. For this reviewer it opens a new world, not only sics with clinical experience up to December 2001. The concerning angiogenesis (sprouting of endothelial cells) common goal: Progress in therapy, both surgical and and vascularisation (morphogenic differentiation and medical, realizing how difficult, and at times frustrating, blood perfusion—the reader might know the book: Dr. it is to treat these different soft tissue tumors. Folkman’s War: Angiogenesis and the Defeat of Cancer) The contents are divided into 5 chapters. First, there but also new horizons on topics like the phases of apop- is a histological classification of soft, non epithelial tis- tosis, or on the 39 human genes presently known to be sue tumors. This includes benign fibromas as well as fi- involved in repairing our DNA-alterations. A list of 242 brosarcomas, lipomas and liposarcomas, benign and ma- references concludes this chapter. The next covers new lignant synovial tumors, neurofibromas, malignant mela- modalities of therapy and their clinical relevance: gene noma etc. Grading and staging systems and prognostic therapy, the tumor suppressor gene p53, tumor-angiogen- factors, are outlined. Causes for the development of sar- esis and experimental possibilities. In the final chapter comas are discussed. The second chapter is on incidence, current therapies are discussed: radical surgery with an diagnosis, treatment possibilities with their results, and overall recurrence rate of around 25 per cent, and the fu- ture of gene-therapy, with 472 actual studies under way at the end of 2001. A fascinating and demanding book to L. Clodius ( ) Zurich, Switzerland study.
European Journal of Plastic Surgery – Springer Journals
Published: Sep 1, 2003
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