Extreme Evolutionary Conservation of CaSox4 Gene* in Alligator sinensis*

Extreme Evolutionary Conservation of CaSox4 Gene* in Alligator sinensis* The Sox genes form a gene family related by homology to the high-mobility-group (HMG) box region of the testis-determining gene, SRY.Using degenerate primer PCR, we have cloned and sequenced the HMG-box motif ofCaSox4 gene from genomic DNA of the Chinese alligator,Alligator sinensis, a species closely related to American alligator, Alligator mississippiensis. Sequence comparison showed that CaSox4 gene shared 97% homology at the nucleotide level and complete identity at the amino acid level, respectively, withAES4 gene of A. mississippiensis. It indicates that the Sox4gene has been extremely conserved during evolution. The result obtained in the present study strongly suggests that theSox4 gene did not diverge during the differentiation of two closely related alligators, which are thought to have originated from a common ancestor and have existed largely unchanged for 200–250 Myr. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Extreme Evolutionary Conservation of CaSox4 Gene* in Alligator sinensis*

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Kluwer Academic Publishers-Plenum Publishers
Copyright © 2003 by MAIK “Nauka/Interperiodica”
Biomedicine; Human Genetics
Publisher site
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