Extravasation of clarithromycin

Extravasation of clarithromycin Eur J Plast Surg (1998) 21:160±161  Springer-Verlag 1998 LETTER T O T HE EDITOR G. OToole ´ E. Eltigani ´ H. Henderson Received: 20 May 1997 / Accepted: 5 August 1997 Sir: To our knowledge, severe injury from extravasated clari- thromycin has not been reported in the literature. We were recently referred an 18-year-old man with such an injury. The clarithromycin had been administered incorrectly, as a concentrated solution (500 mg in 10 ml of saline), too rapidly and through a vein in the dorsum of the hand. It should be given in dilute solution (500 mg in 250 ml of saline), over 60 min, through a proximal vein [1]. During its administration, the patient complained of severe pain, which was diagnosed wrongly as phlebitis. Gradually the hand become increasingly swollen and ischaemic, and the diagnosis became clear (Figs. 1±3). The patient was re- ferred to our unit, 12 h after the injury. Since extravasa- tion is a common complication of intravenous therapy [2, 3], it is surprising that there is no certainty of the best Fig. 1 Dorsum of the hand 12 h after extravasation of clarithromy- cin G. OToole ( ) ´ E. Eltigani ´ H. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Extravasation of clarithromycin

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Publisher
Springer-Verlag
Copyright
Copyright © 1998 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s002380050058
Publisher site
See Article on Publisher Site

Abstract

Eur J Plast Surg (1998) 21:160±161  Springer-Verlag 1998 LETTER T O T HE EDITOR G. OToole ´ E. Eltigani ´ H. Henderson Received: 20 May 1997 / Accepted: 5 August 1997 Sir: To our knowledge, severe injury from extravasated clari- thromycin has not been reported in the literature. We were recently referred an 18-year-old man with such an injury. The clarithromycin had been administered incorrectly, as a concentrated solution (500 mg in 10 ml of saline), too rapidly and through a vein in the dorsum of the hand. It should be given in dilute solution (500 mg in 250 ml of saline), over 60 min, through a proximal vein [1]. During its administration, the patient complained of severe pain, which was diagnosed wrongly as phlebitis. Gradually the hand become increasingly swollen and ischaemic, and the diagnosis became clear (Figs. 1±3). The patient was re- ferred to our unit, 12 h after the injury. Since extravasa- tion is a common complication of intravenous therapy [2, 3], it is surprising that there is no certainty of the best Fig. 1 Dorsum of the hand 12 h after extravasation of clarithromy- cin G. OToole ( ) ´ E. Eltigani ´ H.

Journal

European Journal of Plastic SurgerySpringer Journals

Published: Feb 1, 1998

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