Eur J Plast Surg (1998) 21:160±161 Springer-Verlag 1998 LETTER T O T HE EDITOR G. OToole ´ E. Eltigani ´ H. Henderson Received: 20 May 1997 / Accepted: 5 August 1997 Sir: To our knowledge, severe injury from extravasated clari- thromycin has not been reported in the literature. We were recently referred an 18-year-old man with such an injury. The clarithromycin had been administered incorrectly, as a concentrated solution (500 mg in 10 ml of saline), too rapidly and through a vein in the dorsum of the hand. It should be given in dilute solution (500 mg in 250 ml of saline), over 60 min, through a proximal vein . During its administration, the patient complained of severe pain, which was diagnosed wrongly as phlebitis. Gradually the hand become increasingly swollen and ischaemic, and the diagnosis became clear (Figs. 1±3). The patient was re- ferred to our unit, 12 h after the injury. Since extravasa- tion is a common complication of intravenous therapy [2, 3], it is surprising that there is no certainty of the best Fig. 1 Dorsum of the hand 12 h after extravasation of clarithromy- cin G. OToole ( ) ´ E. Eltigani ´ H.
European Journal of Plastic Surgery – Springer Journals
Published: Feb 1, 1998
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