Access the full text.
Sign up today, get DeepDyve free for 14 days.
M Hikida, M Mori, T Takai (1996)
Reexpression of RAG-1 and RAG-2 Genes in Activated Mature Mouse B CellsScience, 274
L Mincheva-Nilsson, M Kling, S Hammarstrem (1997)
Gamma Delta T Cells of Human Early Pregnancy Decidua: Evidence for Local Proliferation, Phenotypic Heterogeneity, and Extrathymic DifferentiationJ. Immunol., 159
SV Shirshev, EM Kuklina, AYu Maksimov (2007)
Extrathymic Rearrangement of αβT-Lymphocyte Antigen Receptor Genes during PregnancyBiochemistry (Moscow), 72
G Chaouat, N Kiger, TG Wegmann (1983)
Vaccination against Spontaneous Abortion in MiceJ. Reprod. Immunol., 5
X Wei, L Jing, G Meiyu (2005)
Potentiation of T Cell Function by a Marine Algae-Derived Sulfated Polymannuroguluronate: In vitro Analysis of Novel MechanismsJ. Pharmacol. Sci., 97
Y Lin, Y Zeng, J Zhao (2004)
Murine CD45+CD86+ Cells Isolated from Para-Aortic Lymph Nodes in an Abortion-Prone ModelJ. Reprod. Immunol., 64
TG Wegmann, L Hui, L Guilbert (1993)
Bidirectional Cytokine Interactions in the Maternal-Fetal Relationship: Is Successful Pregnancy a Th2 Phenomenon?Immunol. Today, 14
EM Kuklina (2010)
Pregnancy and AutoimmunityRoss. Immunol. Zh., 4
GM Vaitaitis, M Poulin, RJ Sanderson (2003)
Cutting Edge: CD40-Induced Expression of Recombination Activating Gene (RAG) 1 and RAG2: A Mechanism for the Generation of Autoaggressive T Cells in the PeripheryJ. Immunol., 170
DW Bianchi, GK Zickwolf, GJ Weil (1996)
Male Fetal Progenitor Cells Persist in Maternal Blood for as Long as 27 Years PostpartumProc. Natl. Acad. Sci. U.S.A., 93
K O’Donoghue, J Chan, J Fuente (2004)
Microchimerism in Female Bone Marrow and Bone Decades after Fetal Mesenchymal Stem-Cell Trafficking in PregnancyLancet, 364
EM Kuklina (2006)
Revision of the Antigen Receptor of T-LymphocytesBiochemistry (Moscow), 71
EA Robey, BJ Fowlkes (1998)
The Alpha Beta Versus Gamma Delta T-Cell Lineage ChoiceCurr. Opin. Immunol., 10
We studied reactivity of αβT-lymphocytes in CBA pregnant females toward male antigens and the presence of gene rearrangement in T-cells antigen receptor in peripheral lymphoid organs of mice in the case of three breeding variants: CBA × BALB/c (normal allogenic pregnancy), CBA × CBA (syngenetic pregnancy), and CBA × DBA/2 (prone to abortion combination). It was shown that proliferative response of αβT-lymphocytes in pregnant CBA females to male spleen cells was the most marked at normal allogenic pregnancy, the least marked at syngenic pregnancy, and was not observed at the combination CBA × DBA/2. In addition, cells of paraaortic lymphatic nodes (draining uterus) respond to male antigen reliably more effectively than lymphocytes in mesenterial and axillary lymphatic nodes. Simultaneous estimation of recombinase RAG-1, the key enzyme in rearrangement of T-receptor genes, revealed similar principles: predominant activity of recombinase in T-lymphocytes in paraaortal lymphatic nodes of CBA pregnant females. This points to the relationship between extrathymic rearrangement of antigen receptor genes and change in the antigen-detecting repertoire of these cells. The possible biological significance of the discovered phenomenon is discussed.
Russian Journal of Developmental Biology – Springer Journals
Published: Mar 21, 2013
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.