Extracellular Matrix Expression and Production in Fibroblast-Collagen Gels: Towards an In Vitro Model for Ligament Wound Healing

Extracellular Matrix Expression and Production in Fibroblast-Collagen Gels: Towards an In Vitro... Annals of Biomedical Engineering ( 2018) https://doi.org/10.1007/s10439-018-2064-0 Extracellular Matrix Expression and Production in Fibroblast-Collagen Gels: Towards an In Vitro Model for Ligament Wound Healing 1,2 1,2 3 2 STEPHANIE M. FRAHS, JULIA THOM OXFORD, ERICA E. NEUMANN, RAQUEL J. BROWN, 2 2 3 CYNTHIA R. KELLER-PECK, XINZHU PU, and TREVOR J. LUJAN 1 2 Biomolecular Sciences Graduate Program, Boise State University, Boise, ID, USA; Biomolecular Research Center, Boise State University, Boise, ID, USA; and Department of Mechanical & Biomedical Engineering, Boise State University, 1910 University Drive, Boise, ID 83725-2085, USA (Received 1 February 2018; accepted 25 May 2018) Associate Editor Jennifer West oversaw the review of this article. Abstract—Ligament wound healing involves the prolifera- healing follows a sequence of events that results in cell tion of a dense and disorganized fibrous matrix that slowly activation and the production and remodeling of the remodels into scar tissue at the injury site. This remodeling 43 extracellular matrix. Fibroblasts are the primary cells process does not fully restore the highly aligned collagen that create and modify the ligamentous scar tissue, a network that exists in native tissue, and consequently fibrous type I collagen network that provides struc- repaired ligament has decreased strength http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Biomedical Engineering Springer Journals

Extracellular Matrix Expression and Production in Fibroblast-Collagen Gels: Towards an In Vitro Model for Ligament Wound Healing

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Publisher
Springer US
Copyright
Copyright © 2018 by Biomedical Engineering Society
Subject
Biomedicine; Biomedicine, general; Biomedical Engineering; Biological and Medical Physics, Biophysics; Classical Mechanics; Biochemistry, general
ISSN
0090-6964
eISSN
1573-9686
D.O.I.
10.1007/s10439-018-2064-0
Publisher site
See Article on Publisher Site

Abstract

Annals of Biomedical Engineering ( 2018) https://doi.org/10.1007/s10439-018-2064-0 Extracellular Matrix Expression and Production in Fibroblast-Collagen Gels: Towards an In Vitro Model for Ligament Wound Healing 1,2 1,2 3 2 STEPHANIE M. FRAHS, JULIA THOM OXFORD, ERICA E. NEUMANN, RAQUEL J. BROWN, 2 2 3 CYNTHIA R. KELLER-PECK, XINZHU PU, and TREVOR J. LUJAN 1 2 Biomolecular Sciences Graduate Program, Boise State University, Boise, ID, USA; Biomolecular Research Center, Boise State University, Boise, ID, USA; and Department of Mechanical & Biomedical Engineering, Boise State University, 1910 University Drive, Boise, ID 83725-2085, USA (Received 1 February 2018; accepted 25 May 2018) Associate Editor Jennifer West oversaw the review of this article. Abstract—Ligament wound healing involves the prolifera- healing follows a sequence of events that results in cell tion of a dense and disorganized fibrous matrix that slowly activation and the production and remodeling of the remodels into scar tissue at the injury site. This remodeling 43 extracellular matrix. Fibroblasts are the primary cells process does not fully restore the highly aligned collagen that create and modify the ligamentous scar tissue, a network that exists in native tissue, and consequently fibrous type I collagen network that provides struc- repaired ligament has decreased strength

Journal

Annals of Biomedical EngineeringSpringer Journals

Published: Jun 5, 2018

References

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