Annals of Biomedical Engineering ( 2018) https://doi.org/10.1007/s10439-018-2064-0 Extracellular Matrix Expression and Production in Fibroblast-Collagen Gels: Towards an In Vitro Model for Ligament Wound Healing 1,2 1,2 3 2 STEPHANIE M. FRAHS, JULIA THOM OXFORD, ERICA E. NEUMANN, RAQUEL J. BROWN, 2 2 3 CYNTHIA R. KELLER-PECK, XINZHU PU, and TREVOR J. LUJAN 1 2 Biomolecular Sciences Graduate Program, Boise State University, Boise, ID, USA; Biomolecular Research Center, Boise State University, Boise, ID, USA; and Department of Mechanical & Biomedical Engineering, Boise State University, 1910 University Drive, Boise, ID 83725-2085, USA (Received 1 February 2018; accepted 25 May 2018) Associate Editor Jennifer West oversaw the review of this article. Abstract—Ligament wound healing involves the prolifera- healing follows a sequence of events that results in cell tion of a dense and disorganized ﬁbrous matrix that slowly activation and the production and remodeling of the remodels into scar tissue at the injury site. This remodeling 43 extracellular matrix. Fibroblasts are the primary cells process does not fully restore the highly aligned collagen that create and modify the ligamentous scar tissue, a network that exists in native tissue, and consequently ﬁbrous type I collagen network that provides struc- repaired ligament has decreased strength
Annals of Biomedical Engineering – Springer Journals
Published: Jun 5, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera