Rationale The low self-administration (LS)/Kgras (LS) and ence scores compared to LS and reduced basal extracellular high self-administration (HS)/Kgras (HS) rat lines were gen- concentrations of dopamine and acetylcholine. However, pat- erated by selective breeding for low- and high-intravenous terns of neurotransmitter release did not differ between strains. cocaine self-administration, respectively, from a common out- Low-dose cocaine increased locomotor activity in LS rats, but bred Wistar stock (Crl:WI). This trait has remained stable after not in HS animals, while high-dose cocaine augmented activ- 13 generations of breeding. ity only in HS rats. Either dose of cocaine increased immuno- Objective The objective of the present study is to compare reactivity for c-Fos in the NA shell of both strains, with greater cocaine preference, neurotransmitter release, and dopamine elevations observed in HS rats. Activation identified by cells receptor activation in LS and HS rats. expressing both c-Fos and dopamine receptors was generally Methods Levels of dopamine, acetylcholine, and cocaine greater in the HS strain, with a similar pattern for both D1 and were measured in the nucleus accumbens (NA) shell of HS D2 dopamine receptors. and LS rats by tandem mass spectrometry of microdialysates. Conclusions Diminished levels of dopamine and acetylcho-
Psychopharmacology – Springer Journals
Published: May 26, 2017
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