Extensive Gastrointestinal Manifestations as the Main Relapsing Disease in Granulomatosis with Polyangiitis

Extensive Gastrointestinal Manifestations as the Main Relapsing Disease in Granulomatosis with... Digestive Diseases and Sciences (2018) 63:2810–2812 https://doi.org/10.1007/s10620-018-5147-8 C ASE REPOR T Extensive Gastrointestinal Manifestations as the Main Relapsing Disease in Granulomatosis with Polyangiitis 1 2 3 1 Omar Vergara‑Fernández  · Fredy Chablé‑Montero  · Natllely Ruiz  · David Mitre‑Reyes  · 4 5 3 3,6 Eduardo Cerda‑Contreras  · Andrea Hernández  · Erika Marroquín‑Fabián  · Luis Felipe Flores‑Suárez Received: 15 October 2017 / Accepted: 28 May 2018 / Published online: 4 June 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 Keywords Granulomatosis with polyangiitis · ANCA · Vasculitis · Gastrointestinal · Anorectal Granulomatosis with polyangiitis (GPA-Wegener’s) is (nodular disease, biopsy-proven), was treated with glucocor- a small vessel vasculitis associated with the presence of ticoids (GC) and methotrexate (MTX) as remission induc- antineutrophil cytoplasm autoantibodies. Gastrointestinal tion therapy, followed by MTX as maintenance treatment for involvement ranges from 5 to 20% of cases. We describe a 5 years. After remission was achieved at month 6, gradual case in whom relapsing disease with widespread gastrointes- tapering of MTX during the following 4.5 years allowed for tinal manifestations including pharyngeal, esophageal, small its withdrawal in 2010. He already had a history of a hemor- and large intestine, and anus was present for the first time. rhoidal disease, leading in 2013 to ferropenic anemia, which A 43-years-old male, with a 10-year history http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Digestive Diseases and Sciences Springer Journals

Extensive Gastrointestinal Manifestations as the Main Relapsing Disease in Granulomatosis with Polyangiitis

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Gastroenterology; Hepatology; Oncology; Transplant Surgery; Biochemistry, general
ISSN
0163-2116
eISSN
1573-2568
D.O.I.
10.1007/s10620-018-5147-8
Publisher site
See Article on Publisher Site

Abstract

Digestive Diseases and Sciences (2018) 63:2810–2812 https://doi.org/10.1007/s10620-018-5147-8 C ASE REPOR T Extensive Gastrointestinal Manifestations as the Main Relapsing Disease in Granulomatosis with Polyangiitis 1 2 3 1 Omar Vergara‑Fernández  · Fredy Chablé‑Montero  · Natllely Ruiz  · David Mitre‑Reyes  · 4 5 3 3,6 Eduardo Cerda‑Contreras  · Andrea Hernández  · Erika Marroquín‑Fabián  · Luis Felipe Flores‑Suárez Received: 15 October 2017 / Accepted: 28 May 2018 / Published online: 4 June 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 Keywords Granulomatosis with polyangiitis · ANCA · Vasculitis · Gastrointestinal · Anorectal Granulomatosis with polyangiitis (GPA-Wegener’s) is (nodular disease, biopsy-proven), was treated with glucocor- a small vessel vasculitis associated with the presence of ticoids (GC) and methotrexate (MTX) as remission induc- antineutrophil cytoplasm autoantibodies. Gastrointestinal tion therapy, followed by MTX as maintenance treatment for involvement ranges from 5 to 20% of cases. We describe a 5 years. After remission was achieved at month 6, gradual case in whom relapsing disease with widespread gastrointes- tapering of MTX during the following 4.5 years allowed for tinal manifestations including pharyngeal, esophageal, small its withdrawal in 2010. He already had a history of a hemor- and large intestine, and anus was present for the first time. rhoidal disease, leading in 2013 to ferropenic anemia, which A 43-years-old male, with a 10-year history

Journal

Digestive Diseases and SciencesSpringer Journals

Published: Jun 4, 2018

References

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