Pharm Res (2018) 35:153 https://doi.org/10.1007/s11095-018-2435-0 RESEARCH PAPER Extended Pharmacokinetic Model of the Rabbit Eye for Intravitreal and Intracameral Injections of Macromolecules: Quantitative Analysis of Anterior and Posterior Elimination Pathways 1 1 2 3 4 Marko Lamminsalo & Ella Taskinen & Timo Karvinen & Astrid Subrizi & Lasse Murtomäki & 1,5,6 1 Arto Urtti & Veli-Pekka Ranta Received: 23 April 2018 /Accepted: 22 May 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT well-stirred anterior chamber (57 min). In IVT injections of Purpose To extend the physiological features of the anatom- FITC-dextrans a good match between simulations and in vivo ically accurate model of the rabbit eye for intravitreal (IVT) data was obtained when the percentage of anterior elimination and intracameral (IC) injections of macromolecules. pathway was over 80%. Methods The computational fluid dynamic model of the rab- Conclusions The simulations with the extended model closely bit eye by Missel (2012) was extended by enhancing the resemble in vivo pharmacokinetics, and the model is a valuable mixing in the anterior chamber with thermal gradient, heat tool for data interpretation and predictions. transfer and gravity, and studying its effect on IC injections of hyaluronic acids. In IVT injections of
Pharmaceutical Research – Springer Journals
Published: May 31, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera