Expression of the proopiomelanocortin (POMC) gene in NISAG rats with inherited stress-induced arterial hypertension has been investigated by the reverse transcription–competitive PCR method. Normotensive rats of the inbred Wistar Albino Glaxo (WAG) strain have been used as control. The effect of 3 h immobilization stress has been examined. The content of POMC mRNA in pituitaries of stressed NISAG rats exceeds that in nonstressed rats of the same strain by a factor of 2.4. Rats of the WAG strain do not demonstrate a significant increase in the level of POMC mRNA. In addition, the basic transcription level of the POMC gene in NISAG rats is higher than in WAG ones.
Russian Journal of Genetics – Springer Journals
Published: Oct 16, 2004
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