Expression of the Proopiomelanocortin Gene in the Pituitaries of Rats of the Hypertensive Strain NISAG

Expression of the Proopiomelanocortin Gene in the Pituitaries of Rats of the Hypertensive Strain... Expression of the proopiomelanocortin (POMC) gene in NISAG rats with inherited stress-induced arterial hypertension has been investigated by the reverse transcription–competitive PCR method. Normotensive rats of the inbred Wistar Albino Glaxo (WAG) strain have been used as control. The effect of 3 h immobilization stress has been examined. The content of POMC mRNA in pituitaries of stressed NISAG rats exceeds that in nonstressed rats of the same strain by a factor of 2.4. Rats of the WAG strain do not demonstrate a significant increase in the level of POMC mRNA. In addition, the basic transcription level of the POMC gene in NISAG rats is higher than in WAG ones. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Expression of the Proopiomelanocortin Gene in the Pituitaries of Rats of the Hypertensive Strain NISAG

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2001 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1016618715644
Publisher site
See Article on Publisher Site

Abstract

Expression of the proopiomelanocortin (POMC) gene in NISAG rats with inherited stress-induced arterial hypertension has been investigated by the reverse transcription–competitive PCR method. Normotensive rats of the inbred Wistar Albino Glaxo (WAG) strain have been used as control. The effect of 3 h immobilization stress has been examined. The content of POMC mRNA in pituitaries of stressed NISAG rats exceeds that in nonstressed rats of the same strain by a factor of 2.4. Rats of the WAG strain do not demonstrate a significant increase in the level of POMC mRNA. In addition, the basic transcription level of the POMC gene in NISAG rats is higher than in WAG ones.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 16, 2004

References

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