Expression of podoplanin in stromal fibroblasts plays a pivotal role in the prognosis of patients with pancreatic cancer

Expression of podoplanin in stromal fibroblasts plays a pivotal role in the prognosis of patients... Introduction Purpose To investigate the role of podoplanin (PDPN) expression in invasive ductal carcinoma of the pancreas Pancreatic cancer is associated with one of the poorest (IDCP) in humans. prognoses of any cancer because early detection is diffi - Methods Tumor samples were obtained from 95 patients cult and it progresses rapidly [1–3]. The number of deaths with IDCP. Immunohistochemical staining was done to from pancreatic cancer is increasing in Japan. In fact, more evaluate the expression of PDPN in cancer tissues. than 30,000 deaths from pancreatic cancer in 2013 slightly Results PDPN was detected predominantly in stromal exceeded the number of deaths from liver cancer in the fibroblasts, stained with α-smooth muscle actin. The cutoff same year [4]. value of PDPN-positive areas was calculated according to Pancreatic fibrosis is one of the histopathologic findings a histogram. There was no significant difference in clin - at the time of the desmoplastic reaction associated with icopathologic factors between patients with high vs. those chronic pancreatitis or pancreatic cancer. Pancreatic stel- with low PDPN expression. The high PDPN group showed late cells (PSCs) were first isolated and identified in the significantly poorer disease-free and disease-specific sur - pancreas in 1998 [5, Surgery Today Springer Journals

Expression of podoplanin in stromal fibroblasts plays a pivotal role in the prognosis of patients with pancreatic cancer

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Springer Japan
Copyright © 2017 by The Author(s)
Medicine & Public Health; Surgery; Surgical Oncology
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