Introduction Purpose To investigate the role of podoplanin (PDPN) expression in invasive ductal carcinoma of the pancreas Pancreatic cancer is associated with one of the poorest (IDCP) in humans. prognoses of any cancer because early detection is diffi - Methods Tumor samples were obtained from 95 patients cult and it progresses rapidly [1–3]. The number of deaths with IDCP. Immunohistochemical staining was done to from pancreatic cancer is increasing in Japan. In fact, more evaluate the expression of PDPN in cancer tissues. than 30,000 deaths from pancreatic cancer in 2013 slightly Results PDPN was detected predominantly in stromal exceeded the number of deaths from liver cancer in the fibroblasts, stained with α-smooth muscle actin. The cutoff same year . value of PDPN-positive areas was calculated according to Pancreatic fibrosis is one of the histopathologic findings a histogram. There was no significant difference in clin - at the time of the desmoplastic reaction associated with icopathologic factors between patients with high vs. those chronic pancreatitis or pancreatic cancer. Pancreatic stel- with low PDPN expression. The high PDPN group showed late cells (PSCs) were first isolated and identified in the significantly poorer disease-free and disease-specific sur - pancreas in 1998 [5,
Surgery Today – Springer Journals
Published: Jul 12, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud