Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma

Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal... Objective Our previous differential transcriptome analysis between a paired specimen of normal and esophageal squamous cell carcinoma (ESCC) tissues found aberrant expression of kallikrein-related peptidase 13 (KLK13) in tumors. In this study, we evaluated the expression of KLK13 in many ESCC cases in relation with clinical features, and the prognosis. Methods Eighty-eight ESCC cases were subjected to immunohistological staining for KLK13 and classified into KLK13- negative and KLK13-positive groups. Difference of clinical features and the prognosis between the groups was analyzed. Results In normal esophageal mucosa, KLK13 expression was evident but limited in the stratum granulosum in all cases. By contrast, only 27 of 88 ESCC samples showed KLK13 expression, whereas the remaining 61 tumors showed no KLK13 expression. The KLK13-positive group was significantly associated with pT classification (deeper tumor invasions; P = 0.0282), pN classification (lymph node metastasis; P = 0.0163), and advanced TNM stage (P = 0.0198). In KLK13- positive samples, KLK13-expressing cells often expressed Ki67, a proliferation marker, unlike normal mucosa, in which Ki67-expressing cells were limited to the basal layer and did not express KLK13. Compared with patients with KLK13- negative group, KLK13-positive group showed poorer postoperative prognosis. Conclusion Relatively high levels of KLK13 expression http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png General Thoracic and Cardiovascular Surgery Springer Journals

Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma

Loading next page...
 
/lp/springer_journal/expression-of-kallikrein-related-peptidase-13-is-associated-with-poor-W0Xm5J1mJ7
Publisher
Springer Japan
Copyright
Copyright © 2018 by The Japanese Association for Thoracic Surgery
Subject
Medicine & Public Health; Thoracic Surgery; Cardiac Surgery; Cardiology; Surgical Oncology
ISSN
1863-6705
eISSN
1863-6713
D.O.I.
10.1007/s11748-018-0910-5
Publisher site
See Article on Publisher Site

Abstract

Objective Our previous differential transcriptome analysis between a paired specimen of normal and esophageal squamous cell carcinoma (ESCC) tissues found aberrant expression of kallikrein-related peptidase 13 (KLK13) in tumors. In this study, we evaluated the expression of KLK13 in many ESCC cases in relation with clinical features, and the prognosis. Methods Eighty-eight ESCC cases were subjected to immunohistological staining for KLK13 and classified into KLK13- negative and KLK13-positive groups. Difference of clinical features and the prognosis between the groups was analyzed. Results In normal esophageal mucosa, KLK13 expression was evident but limited in the stratum granulosum in all cases. By contrast, only 27 of 88 ESCC samples showed KLK13 expression, whereas the remaining 61 tumors showed no KLK13 expression. The KLK13-positive group was significantly associated with pT classification (deeper tumor invasions; P = 0.0282), pN classification (lymph node metastasis; P = 0.0163), and advanced TNM stage (P = 0.0198). In KLK13- positive samples, KLK13-expressing cells often expressed Ki67, a proliferation marker, unlike normal mucosa, in which Ki67-expressing cells were limited to the basal layer and did not express KLK13. Compared with patients with KLK13- negative group, KLK13-positive group showed poorer postoperative prognosis. Conclusion Relatively high levels of KLK13 expression

Journal

General Thoracic and Cardiovascular SurgerySpringer Journals

Published: Mar 26, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off