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Zhong Huang, G. Elkin, Bryan Maloney, Norene Beuhner, C. Arntzen, Y. Thanavala, H. Mason (2005)
Virus-like particle expression and assembly in plants: hepatitis B and Norwalk viruses.Vaccine, 23 15
David Brayden, M. Jepson, A. Baird (2005)
Keynote review: intestinal Peyer's patch M cells and oral vaccine targeting.Drug discovery today, 10 17
S. Kumar, A. Dhingra, H. Daniell (2004)
Plastid-Expressed Betaine Aldehyde Dehydrogenase Gene in Carrot Cultured Cells, Roots, and Leaves Confers Enhanced Salt Tolerance1Plant Physiology, 136
Mi-Young Kim, Moon-Sik Yang, Tae-Geum Kim (2009)
Expression of dengue virus E glycoprotein domain III in non-nicotine transgenic tobacco plantsBiotechnology and Bioprocess Engineering, 14
A. Barrett (2001)
Current Status of Flavivirus VaccinesAnnals of the New York Academy of Sciences, 951
K. Matsui, Gregory Gromowski, Li Li, A. Schuh, J. Lee, A. Barrett (2009)
Characterization of dengue complex-reactive epitopes on dengue 3 virus envelope protein domain III.Virology, 384 1
M. Manchester, N. Steinmetz (2009)
Viruses and nanotechnology
R. Suzuki, E. Winkelmann, P. Mason (2008)
Construction and Characterization of a Single-Cycle Chimeric Flavivirus Vaccine Candidate That Protects Mice against Lethal Challenge with Dengue Virus Type 2Journal of Virology, 83
B. Fonseca, S. Pincus, R. Shope, E. Paoletti, P. Mason (1994)
Recombinant vaccinia viruses co-expressing dengue-1 glycoproteins prM and E induce neutralizing antibodies in mice.Vaccine, 12 3
Long Li, S. Lok, I. Yu, Ying Zhang, R. Kuhn, Jue Chen, M. Rossmann (2008)
The Flavivirus Precursor Membrane-Envelope Protein Complex: Structure and MaturationScience, 319
Y. Nagao, K. Koelle (2008)
Decreases in dengue transmission may act to increase the incidence of dengue hemorrhagic feverProceedings of the National Academy of Sciences, 105
Tracey Ruhlman, R. Ahangari, A. Devine, M. Samsam, H. Daniell (2007)
Expression of cholera toxin B-proinsulin fusion protein in lettuce and tobacco chloroplasts--oral administration protects against development of insulitis in non-obese diabetic mice.Plant biotechnology journal, 5 4
R. Sugrue, Taian Cui, Qiurong Xu, Jianlin Fu, Yow Chan (1997)
The production of recombinant dengue virus E protein using Escherichia coli and Pichia pastoris.Journal of virological methods, 69 1-2
Tracey Ruhlman, D. Verma, Nalapalli Samson, H. Daniell (2010)
The Role of Heterologous Chloroplast Sequence Elements in Transgene Integration and Expression1[W][OA]Plant Physiology, 152
Marc‐André D'Aoust, M. Couture, N. Charland, S. Trépanier, N. Landry, Frédéric Ors, L. Vézina (2010)
The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza.Plant biotechnology journal, 8 5
D. Webster, J. Farrar, S. Rowland-Jones (2009)
Progress towards a dengue vaccine.The Lancet. Infectious diseases, 9 11
S. Paula, D. Lima, Rafael França, A. Gomes-Ruiz, B. Fonseca (2008)
A DNA vaccine candidate expressing dengue-3 virus prM and E proteins elicits neutralizing antibodies and protects mice against lethal challengeArchives of Virology, 153
E. Konishi, A. Fujii (2002)
Dengue type 2 virus subviral extracellular particles produced by a stably transfected mammalian cell line and their evaluation for a subunit vaccine.Vaccine, 20 7-8
L. Santi, Zhong Huang, H. Mason (2006)
Virus-like particles production in green plants.Methods, 40 1
J. Kyle, E. Harris (2008)
Global spread and persistence of dengue.Annual review of microbiology, 62
Erica Strable, M. Finn (2009)
Chemical modification of viruses and virus-like particles.Current topics in microbiology and immunology, 327
E. Kelly, J. Greene, A. King, B. Innis (2000)
Purified dengue 2 virus envelope glycoprotein aggregates produced by baculovirus are immunogenic in mice.Vaccine, 18 23
E. Callaway (2007)
Dengue fever climbs the social ladderNature, 448
I. Lorenz, Steven Allison, F. Heinz, A. Helenius (2002)
Folding and Dimerization of Tick-Borne Encephalitis Virus Envelope Proteins prM and E in the Endoplasmic ReticulumJournal of Virology, 76
H. Daniell, N. Singh, H. Mason, S. Streatfield (2009)
Plant-made vaccine antigens and biopharmaceuticalsTrends in Plant Science, 14
D. Gubler, M. Meltzer (1999)
Impact of dengue/dengue hemorrhagic fever on the developing world.Advances in virus research, 53
Pei-Gang Wang, M. Kudelko, J. Lo, L. Siu, Kevin Kwok, M. Sachse, J. Nicholls, R. Bruzzone, R. Altmeyer, B. Nal (2009)
Efficient Assembly and Secretion of Recombinant Subviral Particles of the Four Dengue Serotypes Using Native prM and E ProteinsPLoS ONE, 4
P. Arlen, R. Falconer, S. Cherukumilli, A. Cole, A. Cole, K. Oishi, H. Daniell (2007)
Field production and functional evaluation of chloroplast-derived interferon-alpha2b.Plant biotechnology journal, 5 4
J. Sambrook, E. Fritsch, T. Maniatis (2001)
Molecular Cloning: A Laboratory Manual
AD Barrett (2001)
Current status of flavivirus vaccinesAnn NY Acad Sci, 951
P. Blair, T. Kochel, K. Raviprakash, C. Guevara, Milagros Salazar, Shuenn-Jue Wu, J. Olson, K. Porter (2006)
Evaluation of immunity and protective efficacy of a dengue-3 pre-membrane and envelope DNA vaccine in Aotus nancymae monkeys.Vaccine, 24 9
S. Ruf, M. Hermann, I. Berger, H. Carrer, R. Bock (2001)
Stable genetic transformation of tomato plastids and expression of a foreign protein in fruitNature Biotechnology, 19
M. Guzmán, G. Kourí (2002)
Dengue: an update.The Lancet. Infectious diseases, 2 1
Songli Wang, R. He, Robert Anderson (1999)
PrM- and Cell-Binding Domains of the Dengue Virus E ProteinJournal of Virology, 73
D. Verma, H. Daniell (2007)
Chloroplast Vector Systems for Biotechnology Applications1Plant Physiology, 145
(2005)
candidates generated by introduction of deletions in the 3 0 untranslated region ( 3 0 - UTR ) or by exchange of the DENV - 3 3 0 - UTR with that of DENV - 4
N. Singh, M. Li, Sueng-Bum Lee, D. Schnell, H. Daniell (2008)
Arabidopsis Tic40 Expression in Tobacco Chloroplasts Results in Massive Proliferation of the Inner Envelope Membrane and Upregulation of Associated ProteinsThe Plant Cell Online, 20
(2005)
Virus-like particle expression and assembly in plants: hepatitis
Wanida Saejung, K. Fujiyama, T. Takasaki, Mikako Ito, K. Hori, P. Malasit, Yuichiro Watanabe, I. Kurane, T. Seki (2007)
Production of dengue 2 envelope domain III in plant using TMV-based vector system.Vaccine, 25 36
Arati Limaye, V. Koya, M. Samsam, H. Daniell (2006)
Receptor‐mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory systemThe FASEB Journal, 20
E. Gould, T. Solomon (2008)
Pathogenic flavivirusesThe Lancet, 371
R. Noad, P. Roy (2003)
Virus-like particles as immunogens.Trends in microbiology, 11 9
S. Halstead (1988)
Pathogenesis of dengue: challenges to molecular biology.Science, 239 4839
P. Arlen, Michael Singleton, J. Adamovicz, Yi Ding, Abdolreza Davoodi-Semiromi, H. Daniell (2008)
Effective Plague Vaccination via Oral Delivery of Plant Cells Expressing F1-V Antigens in ChloroplastsInfection and Immunity, 76
(2006)
Efficient and stable transformation of Lactuca sativa L. cv
D. Verma, Nalapalli Samson, V. Koya, H. Daniell (2008)
A protocol for expression of foreign genes in chloroplastsNature Protocols, 3
P. Lenzi, N. Scotti, F. Alagna, M. Tornesello, A. Pompa, A. Vitale, A. Stradis, L. Monti, S. Grillo, F. Buonaguro, P. Maliga, T. Cardi (2008)
Translational fusion of chloroplast-expressed human papillomavirus type 16 L1 capsid protein enhances antigen accumulation in transplastomic tobaccoTransgenic Research, 17
H. Daniell (1997)
Transformation and Foreign Gene Expression in Plants Mediated by Microprojectile BombardmentMethods of Molecular Biology, 62
L. Santi, L. Batchelor, Zhong Huang, B. Hjelm, J. Kilbourne, C. Arntzen, Qiang Chen, H. Mason (2008)
An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles.Vaccine, 26 15
A. Durbin, S. Whitehead (2010)
Dengue vaccine candidates in development.Current topics in microbiology and immunology, 338
(2009)
Construction and characterization of a single-cycle chimeric flavivirus vaccine candidate that protects mice against lethal challenge with dengue virus
A. Millán, S. Ortigosa, S. Hervás-Stubbs, P. Corral-Martínez, J. Seguí-Simarro, Julien Gaétan, P. Coursaget, J. Veramendi (2008)
Human papillomavirus L1 protein expressed in tobacco chloroplasts self-assembles into virus-like particles that are highly immunogenic.Plant biotechnology journal, 6 5
E. Ooi, K. Goh, D. Gubler (2006)
Dengue Prevention and 35 Years of Vector Control in SingaporeEmerging Infectious Diseases, 12
(2008)
in Aotus nancymae monkeys
Coreen Beaumier, A. Mathew, Hema Bashyam, A. Rothman (2008)
Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner.The Journal of infectious diseases, 197 4
K. Osatomi, H. Sumiyoshi (1990)
Complete nucleotide sequence of dengue type 3 virus genome RNA.Virology, 176 2
M Brightmer, MG Fantato (1998)
Human and environmental factors in the increasing incidence of dengue fever: a case studyVenezuela GeoJournal, 44
A. Walmsley, A. Walmsley, C. Arntzen (2000)
Plants for delivery of edible vaccines.Current opinion in biotechnology, 11 2
C. Noble, Yen-Liang Chen, Hongping Dong, Feng Gu, S. Lim, W. Schul, Qing-yin Wang, P. Shi (2010)
Strategies for development of Dengue virus inhibitors.Antiviral research, 85 3
S. Halstead (2003)
Neutralization and antibody-dependent enhancement of dengue viruses.Advances in virus research, 60
H. Kanamoto, A. Yamashita, H. Asao, S. Okumura, H. Takase, M. Hattori, A. Yokota, K. Tomizawa (2006)
Efficient and Stable Transformation of Lactuca sativa L. cv. Cisco (lettuce) PlastidsTransgenic Research, 15
A. Davoodi-Semiromi, M. Schreiber, Samson Nalapalli, D. Verma, N. Singh, R. Banks, D. Chakrabarti, H. Daniell (2010)
Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery.Plant biotechnology journal, 8 2
H. Daniell (1997)
Transformation and foreign gene expression in plants by microprojectile bombardment.Methods in molecular biology, 62
(2008)
Crossreactive memory CD8(?) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific
A. Davoodi-Semiromi, Nalapalli Samson, H. Daniell (2009)
The green vaccine: A global strategy to combat infectious and autoimmune diseasesHuman Vaccines, 5
S. Kumar, H. Daniell (2004)
Engineering the chloroplast genome for hyperexpression of human therapeutic proteins and vaccine antigens.Methods in molecular biology, 267
D. Verma, B. Moghimi, Paul LoDuca, Harminder Singh, Brad Hoffman, R. Herzog, H. Daniell (2010)
Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B miceProceedings of the National Academy of Sciences, 107
D. Freedman, L. Weld, P. Kozarsky, Tamara Fisk, R. Robins, F. Sonnenburg, J. Keystone, P. Pandey, M. Cetron (2006)
Spectrum of disease and relation to place of exposure among ill returned travelers.The New England journal of medicine, 354 2
Adrian Kuhn, D. Erni, Peter Loretan, Oscar Nierstrasz
Journal of Software Maintenance and Evolution: Research and Practice Software Cartography: Thematic Software Visualization with Consistent Layout ‡
T. Chambers, C. Hahn, R. Galler, C. Rice (1990)
Flavivirus genome organization, expression, and replication.Annual review of microbiology, 44
E. Grgacic, David Anderson (2006)
Virus-like particles: Passport to immune recognitionMethods (San Diego, Calif.), 40
I. Takahashi, T. Nochi, Y. Yuki, H. Kiyono (2009)
New horizon of mucosal immunity and vaccines.Current opinion in immunology, 21 3
M. Brightmer, M. Fantato (1998)
Human and environmental factors in the increasing incidence of dengue fever: a case study from VenezuelaGeoJournal, 44
P. Wright, A. Durbin, S. Whitehead, M. Ikizler, S. Henderson, J. Blaney, B. Thumar, S. Ankrah, M. Rock, B. McKinney, B. Murphy, A. Schmidt (2009)
Phase 1 trial of the dengue virus type 4 vaccine candidate rDEN4{Delta}30-4995 in healthy adult volunteers.The American journal of tropical medicine and hygiene, 81 5
Sang-Moo Kang, Dae-goon Yoo, A. Lipatov, J. Song, C. Davis, F. Quan, Li-mei Chen, R. Donis, R. Compans (2009)
Induction of Long-Term Protective Immune Responses by Influenza H5N1 Virus-Like ParticlesPLoS ONE, 4
S. Whitehead, J. Blaney, A. Durbin, B. Murphy (2007)
Prospects for a dengue virus vaccineNature Reviews Microbiology, 5
SB Halstead (2002)
DengueCurr Opin Infect Dis, 15
Chih-yun Lai, Wen-Yang Tsai, Su-Ru Lin, C. Kao, Hsien-Ping Hu, C. King, Han‐Chung Wu, G. Chang, Wei-Kung Wang (2008)
Antibodies to Envelope Glycoprotein of Dengue Virus during the Natural Course of Infection Are Predominantly Cross-Reactive and Recognize Epitopes Containing Highly Conserved Residues at the Fusion Loop of Domain IIJournal of Virology, 82
J. Blaney, Neeraja Sathe, Laura Goddard, C. Hanson, Tammy Romero, K. Hanley, B. Murphy, S. Whitehead (2008)
Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3' untranslated region (3'-UTR) or by exchange of the DENV-3 3'-UTR with that of DENV-4.Vaccine, 26 6
C. Lelivelt, M. McCabe, C. Newell, C. deSnoo, Kees Dun, I. Birch-Machin, J. Gray, K. Mills, J. Nugent (2005)
Stable Plastid Transformation in Lettuce (Lactuca sativa L.)Plant Molecular Biology, 58
K. Senior (2009)
Dengue vaccine efficacy trials in progressLancet Infectious Diseases, 9
R. Men, Michael Bray, Ching-Juh Lai (1991)
Carboxy-terminally truncated dengue virus envelope glycoproteins expressed on the cell surface and secreted extracellularly exhibit increased immunogenicity in miceJournal of Virology, 65
C. Martínez, E. Topal, A. Giulietti, J. Talou, H. Mason (2010)
Exploring different strategies to express Dengue virus envelope protein in a plant systemBiotechnology Letters, 32
J. Roehrig (2003)
Antigenic structure of flavivirus proteins.Advances in virus research, 59
(2009)
Dengue guidelines for diagnosis, treatment, prevention and control
David Purdy, G. Chang (2005)
Secretion of noninfectious dengue virus-like particles and identification of amino acids in the stem region involved in intracellular retention of envelope protein.Virology, 333 2
Raquel Jimenez, Benedito Fonseca (2000)
Recombinant plasmid expressing a truncated dengue-2 virus E protein without co-expression of prM protein induces partial protection in mice.Vaccine, 19 6
(2007)
Production of dengue
S. Chebolu, H. Daniell (2009)
Chloroplast-Derived Vaccine Antigens and Biopharmaceuticals: Expression, Folding, Assembly and FunctionalityPlant-produced Microbial Vaccines, 332
Y. Modis, Steven Ogata, D. Clements, S. Harrison (2004)
Structure of the dengue virus envelope protein after membrane fusionNature, 427
R. Perera, R. Kuhn (2008)
Structural proteomics of dengue virus.Current opinion in microbiology, 11 4
R. Kirnbauer, J. Taub, Heather Greenstone, R. Roden, Matthias Dürst, L. Gissmann, D. Lowy, J. Schiller (1993)
Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particlesJournal of Virology, 67
Jean-Pierre Scheerlinck, D. Greenwood (2008)
Virus-sized vaccine delivery systems.Drug discovery today, 13 19-20
D. Morens, A. Fauci (2008)
Dengue and hemorrhagic fever: a potential threat to public health in the United States.JAMA, 299 2
Wen-Quan Liu, Hanning Jiang, Jun-mei Zhou, Xiaomeng Yang, Yun-xia Tang, D. Fang, Lifang Jiang (2010)
Recombinant dengue virus-like particles from Pichia pastoris: efficient production and immunological propertiesVirus Genes, 40
D. Clements, B. Coller, M. Lieberman, Steven Ogata, Gordon Wang, Kent Harada, J. Putnak, J. Ivy, M. Mcdonell, G. Bignami, I. Peters, J. Leung, C. Weeks-Levy, E. Nakano, T. Humphreys (2010)
Development of a recombinant tetravalent dengue virus vaccine: immunogenicity and efficacy studies in mice and monkeys.Vaccine, 28 15
Sergio Saldaña, Fernando Guadarrama, Teresa Flores, N. Arias, S. López, C. Arias, R. Ruiz-Medrano, H. Mason, T. Mor, L. Richter, C. Arntzen, M. Lim (2006)
Production of rotavirus-like particles in tomato (Lycopersicon esculentum L.) fruit by expression of capsid proteins VP2 and VP6 and immunological studies.Viral immunology, 19 1
RJ Kuhn, W Zhang, MG Rossmann, SV Pletnev, J Corver, E Lenches, CT Jones, S Mukhopadhyay, PR Chipman, EG Strauss, TS Baker, JH Strauss (2002)
Structure of dengue virus: implications for flavivirus organization, maturation, and fusionCell, 108
Dengue is an acute febrile viral disease with >100 million infections occurring each year and more than half of the world population is at risk. Global resurgence of dengue in many urban centers of the tropics is a major concern. Therefore, development of a successful vaccine is urgently needed that is economical and provide long-lasting protection from dengue virus infections. In this manuscript, we report expression of dengue-3 serotype polyprotein (prM/E) consisting of part of capsid, complete premembrane (prM) and truncated envelope (E) protein in an edible crop lettuce. The dengue sequence was controlled by endogenous Lactuca sativa psbA regulatory elements. PCR and Southern blot analysis confirmed transgene integration into the lettuce chloroplast genome via homologous recombination at the trnI/trnA intergenic spacer region. Western blot analysis showed expression of polyprotein prM/E in different forms as monomers (~65 kDa) or possibly heterodimers (~130 kDa) or multimers. Multimers were solubilized into monomers using guanidine hydrochloride. Transplastomic lettuce plants expressing dengue prM/E vaccine antigens grew normally and transgenes were inherited in the T1 progeny without any segregation. Transmission electron microscopy showed the presence of virus-like particles of ~20 nm diameter in chloroplast extracts of transplastomic lettuce expressing prM/E proteins, but not in untransformed plants. The prM/E antigens expressed in lettuce chloroplasts should offer a potential source for investigating an oral Dengue vaccine.
Plant Molecular Biology – Springer Journals
Published: Mar 24, 2011
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