original article Wien Klin Wochenschr (2017) 129:558–563 DOI 10.1007/s00508-017-1173-3 Expression of caveolin-1 in breast cancer stroma as a potential prognostic biomarker of survival and progression: a meta-analysis Xiuying Li · Jinfan Sun · Shuenqin Hu Received: 19 May 2016 / Accepted: 25 January 2017 / Published online: 31 March 2017 © Springer-Verlag Wien 2017 Summary ﬁbroblasts was a signiﬁcant predictor of DFS/PFS Background It has been shown that caveolin-1 (HR = 2.79, 95% CI: 1.75–4.46). plays a potential role as a diagnostic and prognos- Conclusion Our results indicated that lack of expres- tic biomarker in various cancer types. The aim of sion of caveolin-1 in the breast cancer stroma is asso- the present study was to clarify whether caveolin- ciated with a poor prognosis. 1 expressed in the breast cancer stroma could be a prognostic factor for breast cancer patients. Keywords Caveolin-1 · Tumor stroma · Cancer-asso- Methods We searched the PubMed, ScienceDirect and ciated ﬁbroblasts · Breast cancer · Meta-analysis Web of Science databases for published literature in- vestigating associations between stromal caveolin-1 Introduction expression and survival outcome in breast cancer pa- tients. With respect to survival outcomes, the pooled Breast cancer is the most common form of
Wiener klinische Wochenschrift – Springer Journals
Published: Mar 31, 2017
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