Clin Transl Oncol (2017) 19:1091–1098 DOI 10.1007/s12094-017-1643-0 RESEARCH AR TIC L E Expression of anoctamin 1 is associated with advanced tumor stage in patients with non-small cell lung cancer and predicts recurrence after surgery 1 1 2 3 1 1 1 • • • • • • • Y. He H. Li Y. Chen P. Li L. Gao Y. Zheng Y. Sun 1 4 J. Chen X. Qian Received: 27 September 2016 / Accepted: 2 March 2017 / Published online: 15 March 2017 Federacio ´ n de Sociedades Espan ˜ olas de Oncologı ´a (FESEO) 2017 Abstract overexpression was correlated with the high expression of Purpose Anoctamin 1 (ANO1), a recently identiﬁed cal- EGFR and led to an advanced tumor stage. And also high cium-activated chloride channel, has been found to have a ANO1 expression was signiﬁcantly correlated with high critical role in tumorigenesis and tumor progression in recurrence rate at 1-year follow-up. several types of cancer. However, its role in non-small cell Conclusions ANO1 overexpression associated with the lung cancer (NSCLC) remains to be elucidated. In this high expression of EGFR can be a predictive marker of study, we evaluated the utility of ANO1 as a prognostic recurrence
Clinical and Translational Oncology – Springer Journals
Published: Mar 15, 2017
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