Graefes Arch Clin Exp Ophthalmol (2017) 255:1515–1523 DOI 10.1007/s00417-017-3676-z RETINAL DISORDERS Expression of angiopoietin-like protein 8 correlates with VEGF in patients with proliferative diabetic retinopathy 1 2 3 1 Qianyi Lu & Li Lu & Wei Chen & Peirong Lu Received: 21 November 2016 /Revised: 14 March 2017 /Accepted: 18 April 2017 /Published online: 29 April 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract angiogenic and hyperlipidemic factors in the patients with Purpose To investigate the vitreous and serum levels of PDR. These results suggest that ANGPTL-8 is a potential angiopoietin-like protein 8 (ANGPTL-8) and vascular endo- new diagnostic marker and therapeutic target for PDR thelial growth factor (VEGF) in patients with proliferative treatment. diabetic retinopathy (PDR). The serum levels of these factors were also analyzed in patients with diabetes and no diabetic Keywords Angiopoietin-like protein 8 (ANGPTL-8) retinopathy (NDR) and with non-proliferative diabetic reti- Vascular endothelial growth factor (VEGF) Proliferative nopathy (NPDR), to detect the possible correlation between diabetic retinopathy (PDR) Hyperlipidemia the ANGPTL-8 levels and hyperlipidemia. Methods Vitreous samples were obtained from 28 patients with PDR and from 12 patients without diabetes and with Introduction idiopathic macular hole (IMH). Serum samples were also ob- tained from 26 patients with
Graefe's Archive for Clinical and Experimental Ophthalmology – Springer Journals
Published: Apr 29, 2017
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