Access the full text.
Sign up today, get DeepDyve free for 14 days.
T. Dechiara, E. Robertson, A. Efstratiadis (1991)
Parental imprinting of the mouse insulin-like growth factor II geneCell, 64
V. Pachnis, C. Brannan, S. Tilghman (1988)
The structure and expression of a novel gene activated in early mouse embryogenesis.The EMBO Journal, 7
F. Poirier, C. Chan, P. Timmons, J. Elizabeth, Robertson, M. Evans, W. Peter, Rigby (1991)
The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo.Development, 113 4
A. Bell, G. Felsenfeld (2000)
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 geneNature, 405
C. Auffray, F. Rougeon (2005)
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.European journal of biochemistry, 107 2
K. Ishihara, K. Ishihara, K. Ishihara, Naoya Hatano, Naoya Hatano, H. Furuumi, H. Furuumi, Reiko Kato, Reiko Kato, Reiko Kato, Toru Iwaki, Kiyonori Miura, Kiyonori Miura, Yoshihiro Jinno, Yoshihiro Jinno, Hiroyuki Sasaki (2000)
Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting.Genome research, 10 5
P. Leighton, J. Saam, R. Ingram, C. Stewart, M. Pazin (1995)
An enhancer deletion affects both H19 and Igf2 expression.Genes & development, 9 17
L. Riesselmann, T. Haaf (1999)
Preferential S-phase pairing of the imprinted region on distal mouse chromosome 7Cytogenetic and Genome Research, 86
C. Brannan, Elizabeth Dees, R. Ingram, S. Tilghman (1990)
The product of the H19 gene may function as an RNAMolecular and Cellular Biology, 10
V. Pachnis, A. Belayew, S. Tilghman (1984)
Locus unlinked to alpha-fetoprotein under the control of the murine raf and Rif genes.Proceedings of the National Academy of Sciences of the United States of America, 81 17
Beverly Jones, J. Levorse, S. Tilghman (1998)
Igf2 imprinting does not require its own DNA methylation or H19 RNA.Genes & development, 12 14
L Riesselmann, T Haaf (1999)
Preferential S-phase pairing of the imprinted region on distal mouse chromosome 7Cytogenet Cell Genet, 86
Jennifer Schmidt, J. Levorse, S. Tilghman (1999)
Enhancer competition between H19 and Igf2 does not mediate their imprinting.Proceedings of the National Academy of Sciences of the United States of America, 96 17
C. Kaffer, M. Srivastava, K. Park, E. Ives, S. Hsieh, J. Batlle, A. Grinberg, S. Huang, K. Pfeifer (2000)
A transcriptional insulator at the imprinted H19/Igf2 locus.Genes & development, 14 15
A. Hark, C. Schoenherr, D. Katz, R. Ingram, J. Levorse, S. Tilghman (2000)
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locusNature, 405
Karl Pfeifer, P. Leighton, S. Tilghman (1996)
The structural H19 gene is required for transgene imprinting.Proceedings of the National Academy of Sciences of the United States of America, 93 24
T. Dechiara, A. Efstratiadis, Elizabeth Robertsen (1990)
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targetingNature, 345
H. Yoo-Warren, V. Pachnis, R. Ingram, S. Tilghman (1988)
Two regulatory domains flank the mouse H19 geneMolecular and Cellular Biology, 8
P. Leighton, R. Ingram, Jonathan Eggenschwiler, A. Efstratiadis, S. Tilghman (1995)
Disruption of imprinting caused by deletion of the H19 gene region in miceNature, 375
J. Mattick (2004)
RNA regulation: a new genetics?Nature Reviews Genetics, 5
(2001)
Gene Targeting. In Current Protocols in Toxicology (New York: John Wiley and Sons
M. Bartolomei, S. Zemel, S. Tilghman (1991)
Parental imprinting of the mouse H19 geneNature, 351
D. Elson, M. Bartolomei (1997)
A 5' differentially methylated sequence and the 3'-flanking region are necessary for H19 transgene imprintingMolecular and Cellular Biology, 17
J. LaSalle, M. Lalande (1996)
Homologous Association of Oppositely Imprinted Chromosomal DomainsScience, 272
Yue Hao, T. Crenshaw, T. Moulton, E. Newcomb, B. Tycko (1993)
Tumour-suppressor activity of H19 RNANature, 365
M. Brunkow, S. Tilghman (1991)
Ectopic expression of the H19 gene in mice causes prenatal lethality.Genes & development, 5 6
Karen Davies, L. Bowden, PaulR Smith, W. Dean, David Hill, H. Furuumi, H. Sasaki, B. Cattanach, W. Reik (2002)
Disruption of mesodermal enhancers for Igf2 in the minute mutant.Development, 129 7
M. Ripoche, C. Kress, oise Poirier, L. Dandolo (1997)
Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element.Genes & development, 11 12
The imprinted H19 gene produces a noncoding RNA of unknown function. Targeted and transgenic mouse mutations have shown that this RNA can be deleted and overexpressed without adverse effect. Yet one mutation of the H19 gene displayed an embryonic lethal phenotype in the mouse—the expression of an RNA modified by a short insertion near the 5′ end of the transcript (H19 Xba allele). Expression of this RNA in transgenic mice conferred lethality at day 14 of development. The potential for this mutant to elucidate the function of the H19 RNA supported further investigation of the H19 Xba phenotype. Since all H19 Xba transgenic founders died as embryos, an experiment was designed to generate H19 Xba -expressing mice that could be maintained as an established line. This strategy took advantage of the maternal-specific expression of H19, passing an H19 Xba knockin allele silently through males and transferring it to females only to generate animals for study. Surprisingly, H19 Xba knockin mice are fully viable, whether the H19 Xba allele is inherited paternally or maternally. Experiments to reproduce the original transgene-based lethality were also performed and yielded live-born transgene-expressing animals. These data demonstrate that, contrary to published reports, expression of the H19 Xba RNA does not cause embryonic lethality in mice.
Mammalian Genome – Springer Journals
Published: Jan 13, 2006
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.