Mammalian Genome 11, 405–408 (2000). Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Expression-based assay of an X-linked gene to examine effects of the X-controlling element (Xce) locus Robert M. Plenge, Ivona Percec, Joseph H. Nadeau, Huntington F. Willard Department of Genetics, BRB 731, Center for Human Genetics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106-4955, USA, and The Research Institute of University Hospitals of Cleveland, Cleveland, Ohio, USA Received: 23 September 1999 / Accepted: 6 January 2000 Through an incompletely understood process, one of the two X human (Plenge et al. 1997), implying that it is involved in the chromosomes (Chrs) in mammalian XX female cells is inactivated, choice process (Carrel and Willard 1998). Xce appears to map thereby achieving dosage equivalence with XY males (Lyon close to, but downstream of, the Xist gene itself (Simmler et al. 1961). Studies of X;autosome translocations and of chromosom- 1993). It is unclear how (or whether) the two loci interact to ally abnormal embryos suggest that trans-acting autosomal factors control the choice process, although recent work has focused on a interact with cis-acting X-linked elements to “choose” one X to series of differentially methylated repeated
Mammalian Genome – Springer Journals
Published: May 1, 2000
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