Mammalian Genome 8, 352-354 (1997). 9 Spnnger-Verlag New York Inc. 1997 Expression and mapping of the mouse S71Pmsc2 gene, homolog of an essential mitotic gene in yeast Jeremy Allen,* Laurence Colleaux,** Duncan Davidson, Elisabeth Graham, Muriel Lee, Robert Hill, Cathy Abbott,*** Colin Gordon MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland, UK Received: 13 August 1996 / Accepted: 23 December 1996 Polyubiquitinated proteins are degraded by a 26S ATP-dependent stricted distally (Fig. 1B,C). The highest levels are detected in the protease. This large complex contains a proteolytic core, previ- mesenchymal cells at the distal rim of the bud under the apical ously identified as the 20S proteasome, which associates with ectodermal ridge (AER) corresponding to the progress zone. No regulatory components to form the 26S particle (reviewed by Rech- strong hybridization signal is present in the AER itself (Fig. 1D). steiner et al. 1993; Hershko and Ciechanover 1992). Recent studies In E12.5 embryos (Fig. 1E), Pmsc2 is expressed in the mesen- in yeast show that mutations in two of the regulatory components, chyme lining the digits but not throughout the whole of the inter- $4 and $7, interrupt mitosis, indicating a role for the
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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