Expression and mapping of the mouse S7/Pmsc2 gene, homolog of an essential mitotic gene in yeast

Expression and mapping of the mouse S7/Pmsc2 gene, homolog of an essential mitotic gene in yeast Mammalian Genome 8, 352-354 (1997). 9 Spnnger-Verlag New York Inc. 1997 Expression and mapping of the mouse S71Pmsc2 gene, homolog of an essential mitotic gene in yeast Jeremy Allen,* Laurence Colleaux,** Duncan Davidson, Elisabeth Graham, Muriel Lee, Robert Hill, Cathy Abbott,*** Colin Gordon MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland, UK Received: 13 August 1996 / Accepted: 23 December 1996 Polyubiquitinated proteins are degraded by a 26S ATP-dependent stricted distally (Fig. 1B,C). The highest levels are detected in the protease. This large complex contains a proteolytic core, previ- mesenchymal cells at the distal rim of the bud under the apical ously identified as the 20S proteasome, which associates with ectodermal ridge (AER) corresponding to the progress zone. No regulatory components to form the 26S particle (reviewed by Rech- strong hybridization signal is present in the AER itself (Fig. 1D). steiner et al. 1993; Hershko and Ciechanover 1992). Recent studies In E12.5 embryos (Fig. 1E), Pmsc2 is expressed in the mesen- in yeast show that mutations in two of the regulatory components, chyme lining the digits but not throughout the whole of the inter- $4 and $7, interrupt mitosis, indicating a role for the Mammalian Genome Springer Journals

Expression and mapping of the mouse S7/Pmsc2 gene, homolog of an essential mitotic gene in yeast

Loading next page...
Copyright © 1997 by Springer-Verlag
Life Sciences; Cell Biology; Anatomy; Zoology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial