Expression analysis of beta-secretase 1 (BACE1) and its naturally occurring antisense (BACE1-AS) in blood of epileptic patients

Expression analysis of beta-secretase 1 (BACE1) and its naturally occurring antisense (BACE1-AS)... Beta-secretase 1 (BACE1) gene encodes a transmembrane protease from the peptidase A1 family of aspartic proteases whose role in the pathogenesis of Alzheimer’s disease has been assessed. The enzymatic activity of BACE1 on several proteins implicated in epileptogenesis implies its role in the pathogenesis of epilepsy. In the present study, we assessed expression of BACE1 and its naturally occurring antisense (BACE1-AS) in peripheral blood of 40 epileptic patients and 40 age- and sex-matched healthy subjects. We did not detect either any difference in the expression of these genes between cases and controls or significant correlation between their expressions and participants’ age. However, we demonstrated a significant correlation between expres- sion levels of BACE1 and BACE1-AS which supports the previously suggested feed-forward mechanism of regulation between these two transcripts. Future studies in larger sample sizes are needed to elaborate the function of BACE1 in epilepsy. . . Keywords BACE1 BACE1-AS Epilepsy Introduction wide range of tissues [8] in addition to its highest activity in neural tissues [20] imply the participation of BACE1 in other Beta-secretase 1 (BACE1) gene encodes a transmembrane disorders rather than Alzheimer’s disease. In addition to the protease from the peptidase A1 family of aspartic proteases. amyloid http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurological Sciences Springer Journals

Expression analysis of beta-secretase 1 (BACE1) and its naturally occurring antisense (BACE1-AS) in blood of epileptic patients

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Publisher
Springer Milan
Copyright
Copyright © 2018 by Springer-Verlag Italia S.r.l., part of Springer Nature
Subject
Medicine & Public Health; Neurology; Neuroradiology; Neurosurgery; Psychiatry
ISSN
1590-1874
eISSN
1590-3478
D.O.I.
10.1007/s10072-018-3458-3
Publisher site
See Article on Publisher Site

Abstract

Beta-secretase 1 (BACE1) gene encodes a transmembrane protease from the peptidase A1 family of aspartic proteases whose role in the pathogenesis of Alzheimer’s disease has been assessed. The enzymatic activity of BACE1 on several proteins implicated in epileptogenesis implies its role in the pathogenesis of epilepsy. In the present study, we assessed expression of BACE1 and its naturally occurring antisense (BACE1-AS) in peripheral blood of 40 epileptic patients and 40 age- and sex-matched healthy subjects. We did not detect either any difference in the expression of these genes between cases and controls or significant correlation between their expressions and participants’ age. However, we demonstrated a significant correlation between expres- sion levels of BACE1 and BACE1-AS which supports the previously suggested feed-forward mechanism of regulation between these two transcripts. Future studies in larger sample sizes are needed to elaborate the function of BACE1 in epilepsy. . . Keywords BACE1 BACE1-AS Epilepsy Introduction wide range of tissues [8] in addition to its highest activity in neural tissues [20] imply the participation of BACE1 in other Beta-secretase 1 (BACE1) gene encodes a transmembrane disorders rather than Alzheimer’s disease. In addition to the protease from the peptidase A1 family of aspartic proteases. amyloid

Journal

Neurological SciencesSpringer Journals

Published: Jun 2, 2018

References

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