Exploring the Limits of Overhauser Dynamic Nuclear Polarization (O-DNP) for Portable Magnetic Resonance Detection of Low γ Nuclei

Exploring the Limits of Overhauser Dynamic Nuclear Polarization (O-DNP) for Portable Magnetic... Applied Appl Magn Reson Magnetic Resonance https://doi.org/10.1007/s00723-018-1014-1 ORIGINAL PAPER Exploring the Limits of Overhauser Dynamic Nuclear Polarization (O‑DNP) for Portable Magnetic Resonance Detection of Low γ Nuclei 1 2 3 4 J. L. Yoder  · P. E. Magnelind  · M. A. Espy  · M. T. Janicke Received: 8 March 2018 / Revised: 9 April 2018 © Springer-Verlag GmbH Austria, part of Springer Nature 2018 Abstract Nuclear magnetic resonance (NMR) spectroscopy in portable, perma- nent magnet-based spectrometers is primarily limited to nuclei with higher gyro- 1 19 31 magnetic ratio, γ, such as H, F, and P due to the limited field strength achievable in these systems. Overhauser effect dynamic nuclear polarization (O-DNP), which transfers polarization from an unpaired electron to a nucleus by saturating an elec- tron paramagnetic resonance transition with an oscillating radio frequency magnetic field, B , can increase the polarization of low γ nuclei by hundreds or even thou- 1e sands, enabling detection in a portable system. We have investigated the potential for O-DNP to enhance signals using (4-amino-2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO hereafter) as a source of unpaired electrons in a homebuilt ultra-low field (ULF) O-DNP-NMR spectrometer. We have found, in general, that larger concen- trations of TEMPO are required for effective O-DNP with low γ nuclei, which has a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Magnetic Resonance Springer Journals

Exploring the Limits of Overhauser Dynamic Nuclear Polarization (O-DNP) for Portable Magnetic Resonance Detection of Low γ Nuclei

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Publisher
Springer Vienna
Copyright
Copyright © 2018 by Springer-Verlag GmbH Austria, part of Springer Nature
Subject
Physics; Solid State Physics; Spectroscopy/Spectrometry; Atoms and Molecules in Strong Fields, Laser Matter Interaction; Physical Chemistry; Organic Chemistry
ISSN
0937-9347
eISSN
1613-7507
D.O.I.
10.1007/s00723-018-1014-1
Publisher site
See Article on Publisher Site

Abstract

Applied Appl Magn Reson Magnetic Resonance https://doi.org/10.1007/s00723-018-1014-1 ORIGINAL PAPER Exploring the Limits of Overhauser Dynamic Nuclear Polarization (O‑DNP) for Portable Magnetic Resonance Detection of Low γ Nuclei 1 2 3 4 J. L. Yoder  · P. E. Magnelind  · M. A. Espy  · M. T. Janicke Received: 8 March 2018 / Revised: 9 April 2018 © Springer-Verlag GmbH Austria, part of Springer Nature 2018 Abstract Nuclear magnetic resonance (NMR) spectroscopy in portable, perma- nent magnet-based spectrometers is primarily limited to nuclei with higher gyro- 1 19 31 magnetic ratio, γ, such as H, F, and P due to the limited field strength achievable in these systems. Overhauser effect dynamic nuclear polarization (O-DNP), which transfers polarization from an unpaired electron to a nucleus by saturating an elec- tron paramagnetic resonance transition with an oscillating radio frequency magnetic field, B , can increase the polarization of low γ nuclei by hundreds or even thou- 1e sands, enabling detection in a portable system. We have investigated the potential for O-DNP to enhance signals using (4-amino-2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO hereafter) as a source of unpaired electrons in a homebuilt ultra-low field (ULF) O-DNP-NMR spectrometer. We have found, in general, that larger concen- trations of TEMPO are required for effective O-DNP with low γ nuclei, which has a

Journal

Applied Magnetic ResonanceSpringer Journals

Published: May 28, 2018

References

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