Mammalian Genome 12, 668–670 (2001). DOI: 10.1007/s00335-001-1002-9 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 Experimental and computational approaches yield a high-resolution, 1-Mb physical map of the region harboring the mouse t haplotype sterility factor, tcs1 Antonio Planchart, John C. Schimenti The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA Received: 1 February 2001/ Accepted: 10 April 2001 The loci responsible for the phenomena of t haplotype-specific genomic sequence (htgs) database, for sequenced mouse BACs male sterility and high transmission ratio distortion (TRD) map to from this library that map to the sterility-critical region. the inversions that characterize the mouse t complex of Chromo- We began by searching the htgs database, using the sequence some (Chr) 17 (reviewed by Lyon 2000). These loci are referred to of D17Leh48 and Tctex1 as the query sequences. We found two as Tcd1, tcs1, Tcd2 (tcs2), Tcd3 (tcs3), and Tcr1, respectively (Fig. BACs positive for D17Leh48, 147G23 and 248C20, and two 1). The exact nature of the Tcd/tcs (t complex distorter/t complex BACs positive for Tctex1, 103I10 and 103I20. All four were from sterility) factors is unknown, whereas Tcr1 (t complex responder) the RPCI-23 library. Since the data in htgs
Mammalian Genome – Springer Journals
Published: Feb 18, 2014
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