Exclusion of Jagged2 as a candidate for the legless gene

Exclusion of Jagged2 as a candidate for the legless gene Mammalian Genome 9, 778–779 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 1 2 2 2 Sheila M. Bell, Yu Lan, Rulang Jiang, Thomas Gridley Division of Developmental Biology, Children’s Hospital Research Foundation, NRB 3020, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA The Jackson Laboratory, Bar Harbor, Maine 04609, USA Received: 3 February 1998 / Accepted: 6 May 1998 The transgenic insertional mutation, legless (lgl), is characterized by the absence of hindlimb structures distal to the femur, preaxial forelimb abnormalities of variable expressivity, situs inversus in approximately half the progeny, missing olfactory bulbs, and vary- ing degrees of facial clefting (McNeish et al. 1988, 1990). The transgene insertion site was mapped to the distal arm of Chromo- some (Chr) 12 (Singh et al. 1991). Additional characterization of the insertion site with YAC (yeast artificial chromosome) clones Fig. 1. Southern blot analysis. DNA has revealed that the lgl mutation is the result of a deletion of at was isolated from nonmutant (lanes 1 least 600 kb of Chr 12. Genes identified to date within the deleted and 3) and lgl homozygous mutant region include Sp4, which encodes a zinc finger transcription fac- (lanes 2 and 4) pups. The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Exclusion of Jagged2 as a candidate for the legless gene

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Copyright © 1998 by Springer-Verlag New York Inc.
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
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