Mammalian Genome 9, 778–779 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 1 2 2 2 Sheila M. Bell, Yu Lan, Rulang Jiang, Thomas Gridley Division of Developmental Biology, Children’s Hospital Research Foundation, NRB 3020, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA The Jackson Laboratory, Bar Harbor, Maine 04609, USA Received: 3 February 1998 / Accepted: 6 May 1998 The transgenic insertional mutation, legless (lgl), is characterized by the absence of hindlimb structures distal to the femur, preaxial forelimb abnormalities of variable expressivity, situs inversus in approximately half the progeny, missing olfactory bulbs, and vary- ing degrees of facial clefting (McNeish et al. 1988, 1990). The transgene insertion site was mapped to the distal arm of Chromo- some (Chr) 12 (Singh et al. 1991). Additional characterization of the insertion site with YAC (yeast artificial chromosome) clones Fig. 1. Southern blot analysis. DNA has revealed that the lgl mutation is the result of a deletion of at was isolated from nonmutant (lanes 1 least 600 kb of Chr 12. Genes identified to date within the deleted and 3) and lgl homozygous mutant region include Sp4, which encodes a zinc finger transcription fac- (lanes 2 and 4) pups. The
Mammalian Genome – Springer Journals
Published: Sep 1, 1998
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera