Evolutionary conservation of recombination proteins and variability of meiosis-specific proteins of chromosomes

Evolutionary conservation of recombination proteins and variability of meiosis-specific proteins... A comparison of amino acid sequences is performed for orthologs to the meiosis-specific proteins in humans and seven other species, including animals, fungi, and plants that serve as models for the study of molecular mechanisms of meiosis. It is demonstrated that the RAD51 recombination mediator protein is the most conserved of the studied proteins. Its meiotic homolog DMC1 is less conserved, like the MHL1 mismatch-repair protein. The meiosis-specific SPO11 endonuclease is the least conserved among the studied meiotic enzymes. Structural proteins of meiotic chromosomes are poorly conserved. REC8 meiotic cohesin has 6 times lower similarity in the organisms from different kingdoms than its somatic homolog RAD21. The intermediate conservation level is characteristic of the synaptonemal complex proteins containing HORMA domain. Two functional domains of SPO11 endonuclease and MutL Trans_MLH1 domain of MLH1 enzyme are equally or even less conserved than the whole proteins. HORMA functional domain of a number of synaptonemal complex proteins is only 2–3 times more conserved than the whole molecule. Thus, among the key meiotic proteins, the most conserved are proteins responsible for the accuracy of meiotic recombination. Cohesins, synaptonemal complex proteins, and meiosis-specific SPO11 endonuclease are less conserved even within their functional domains. Obviously, the meiosis-specific proteins have undergone independent evolution in different phylogenetic lineages of eukaryotes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Evolutionary conservation of recombination proteins and variability of meiosis-specific proteins of chromosomes

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Publisher
Pleiades Publishing
Copyright
Copyright © 2017 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795417040081
Publisher site
See Article on Publisher Site

Abstract

A comparison of amino acid sequences is performed for orthologs to the meiosis-specific proteins in humans and seven other species, including animals, fungi, and plants that serve as models for the study of molecular mechanisms of meiosis. It is demonstrated that the RAD51 recombination mediator protein is the most conserved of the studied proteins. Its meiotic homolog DMC1 is less conserved, like the MHL1 mismatch-repair protein. The meiosis-specific SPO11 endonuclease is the least conserved among the studied meiotic enzymes. Structural proteins of meiotic chromosomes are poorly conserved. REC8 meiotic cohesin has 6 times lower similarity in the organisms from different kingdoms than its somatic homolog RAD21. The intermediate conservation level is characteristic of the synaptonemal complex proteins containing HORMA domain. Two functional domains of SPO11 endonuclease and MutL Trans_MLH1 domain of MLH1 enzyme are equally or even less conserved than the whole proteins. HORMA functional domain of a number of synaptonemal complex proteins is only 2–3 times more conserved than the whole molecule. Thus, among the key meiotic proteins, the most conserved are proteins responsible for the accuracy of meiotic recombination. Cohesins, synaptonemal complex proteins, and meiosis-specific SPO11 endonuclease are less conserved even within their functional domains. Obviously, the meiosis-specific proteins have undergone independent evolution in different phylogenetic lineages of eukaryotes.

Journal

Russian Journal of Genetics – Springer Journals

Published: Jun 4, 2017

References

  • The core meiotic transcriptome of budding yeast
    Priming, M.; Williams, R.M.; Winzeler, E.A.
  • Expression and chromosomal organization of mouse meiotic genes
    Waldman, B.-A.H.; Shahar, I.; Yitzchak, A.
  • Keeping sister chromatids together: cohesins in meiosis
    Revenkova, E.; Jessberger, R.
  • The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis
    Kitajima, T.S.; Kawashima, S.A.; Watanabe, Y.
  • Synaptonemal complex: structure and function
    Heyting, C.
  • Synaptonemal complex proteins: specific proteins of meiotic chromosomes
    Penkina, M.V.; Karpova, O.I.; Bogdanov, Yu.F.
  • The evolution of meiosis: recruitment and modification of somatic DNA-repair proteins
    Marcon, E.; Moens, P.B.
  • The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination
    Hunter, N.; Kleckner, N.
  • Cloning and characterization of the Kluyveromyces lactis homologs of the Saccharomyces cerevisiae RED1 and HOP1 genes
    Smith, A.V.; Roeder, G.S.
  • Comparative genomics and proteomics of Drosophila
    Bogdanov, Yu.F.; Dadashev, S.Ya.; Grishaeva, T.M.
  • The genetics and molecular biology of the synaptonemal complex
    Page, S.L.; Hawley, R.S.
  • Meiotic chromosomes: integrating structure and function
    Zickler, D.; Kleckner, N.
  • Recombination, pairing
    Zickler, D.; Kleckner, N.
  • A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction
    Pasierbek, P.; Jantsch, M.; Melcher, M.
  • Meiotic Rec8 cohesins and their mitotic Rad21 orthologs: comparison in silico
    Grishaeva, T.M.; Dadashev, S.Ya.; Bogdanov, Yu.F.
  • Isolation and characterization of rad51 orthologs from Coprinus cinereus and Lycopersicon esculentum
    Stassen, N.Y.; Logsdon, J.M.; Vora, G.J.
  • Similarity of the domain structure of proteins as a basis for the conservation of meiosis
    Bogdanov, Yu.F.; Grishaeva, T.M.; Dadashev, S.Ya.
  • Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice
    Kumar, R.; Bourbon, H.-M.; Massy, B.
  • The Drosophila meiotic kleisin C(2)M functions before the meiotic divisions
    Heidmann, D.; Horn, S.; Heidmann, S.
  • The HORMA domain: an evolutionarily conserved domain discovered in chromatin-associated proteins
    Muniyappa, K.; Kshirsagar, R.; Ghodke, I.
  • Conservation and variability of synaptonemal complex proteins in phylogenesis of eukaryotes
    Grishaeva, T.M.; Bogdanov, Yu.F.
  • Spo11 and the formation of DNA doublestrand breaks in meiosis
    Keeney, S.
  • Roles of RecA homologues Rad51 and Dmc1 during meiotic recombination
    Shinohara, A.; Shinohara, M.
  • Evolution of meiosis in unicellular and multicellular eukaryotes: aromorphosis at the cellular level
    Bogdanov, Yu.F.

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