Rotavirus A (RVA) strains, a leading cause of severe gastroenteritis in children worldwide, commonly possess the Wa or DS-1 genotype constellations. During a hospital-based study conducted in Hanoi, Vietnam, in the 2012-2013 rotavirus season, G1P strains with a virtually identical short RNA migration pattern were detected in 20 (14%) of 141 rotavirus-positive samples. Two representatives of these strains were shown by whole-genome sequencing to be double-gene reassortants possessing the genotype constellation of G1-P-I2-R2-C2-M2-A2-N2-T2-E2-H2. Sequencing and a database search revealed that these Vietnamese G1P double-gene reassortant strains shared an immediate ancestor with a locally circulating G2P strain in all of the inner-capsid and non-structural protein genes, whereas they were more closely related in the VP7 and VP4 genes to a Chinese G1P strain and a Chinese G3P strain, respectively, than to locally circulating G1P strains. Despite the marked similarity between Japanese and Thai G1P double-gene reassortant strains, phylogenetic analysis suggested that the Vietnamese and Japanese/Thai G1P double-gene reassortant strains originated from independent reassortment events. Clinically, children infected with Vietnamese G1P double-gene reassortant strains experienced severe diarrhoea, but it was not more severe than that in children infected with ordinary G1P strains. In conclusion, Vietnamese G1P double-gene reassortant strains originated from a locally circulating G2P strain and caused severe diarrhoea, but there was no evidence of increased virulence.
Archives of Virology – Springer Journals
Published: Nov 23, 2016
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