Evidence for natural Borna disease virus infection in healthy domestic animals in three areas of western China

Evidence for natural Borna disease virus infection in healthy domestic animals in three areas of... Borna disease virus (BDV) is a non-cytolytic, neurotropic RNA virus that can infect many vertebrate species, including humans. To date, BDV infection has been reported in a range of animal species across a broad global geographic distribution. However, a systematic epidemiological survey of BDV infection in domesticated animals in China has yet to be performed. In current study, BDV RNA and antibodies in 2353 blood samples from apparently healthy animals of eight species (horse, donkey, dog, pig, rabbit, cattle, goat, sheep) from three areas in western China (Xinjiang province, Chongqing municipality, and Ningxia province) were assayed using reverse transcription qPCR (RT-qPCR) and ELISA assay. Brain tissue samples from a portion of the BDV RNA- and/or antibody-positive animals were subjected to RT-qPCR and western blotting. As a result, varying prevalence of BDV antibodies and/or RNA was demonstrated in various animal species from three areas, ranging from 4.4 % to 20.0 %. Detection of BDV RNA and/or antibodies in Chongqing pigs (9.2 %) provided the first known evidence of BDV infection in this species. Not all brain tissue samples from animals whose blood was BDV RNA and/or antibody positive contained BDV RNA and protein. This study provides evidence that BDV infection among healthy domestic animal species is more widespread in western China than previously believed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Evidence for natural Borna disease virus infection in healthy domestic animals in three areas of western China

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Publisher
Springer Journals
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1971-5
Publisher site
See Article on Publisher Site

Abstract

Borna disease virus (BDV) is a non-cytolytic, neurotropic RNA virus that can infect many vertebrate species, including humans. To date, BDV infection has been reported in a range of animal species across a broad global geographic distribution. However, a systematic epidemiological survey of BDV infection in domesticated animals in China has yet to be performed. In current study, BDV RNA and antibodies in 2353 blood samples from apparently healthy animals of eight species (horse, donkey, dog, pig, rabbit, cattle, goat, sheep) from three areas in western China (Xinjiang province, Chongqing municipality, and Ningxia province) were assayed using reverse transcription qPCR (RT-qPCR) and ELISA assay. Brain tissue samples from a portion of the BDV RNA- and/or antibody-positive animals were subjected to RT-qPCR and western blotting. As a result, varying prevalence of BDV antibodies and/or RNA was demonstrated in various animal species from three areas, ranging from 4.4 % to 20.0 %. Detection of BDV RNA and/or antibodies in Chongqing pigs (9.2 %) provided the first known evidence of BDV infection in this species. Not all brain tissue samples from animals whose blood was BDV RNA and/or antibody positive contained BDV RNA and protein. This study provides evidence that BDV infection among healthy domestic animal species is more widespread in western China than previously believed.

Journal

Archives of VirologySpringer Journals

Published: Aug 1, 2014

References

  • Borna disease virus: evidence of naturally-occurring infection in cats in Australia
    Kamhieh, S; Hodgson, JL; Bode, L; Ludwig, H; Flower, RL
  • No evidence of endemic Borna disease virus infection in Australian horses in contrast with endemic infection in other continents
    Kamhieh, S; Hodgson, J; Bode, L; Ludwig, H; Ward, C; Flower, RL
  • Experimental and natural borna disease virus infections: presence of viral RNA in cells of the peripheral blood
    Vahlenkamp, TW; Enbergs, HK; Muller, H
  • Higher prevalence of Borna disease virus infection in blood donors living near thoroughbred horse farms
    Takahashi, H; Nakaya, T; Nakamura, Y; Asahi, S; Onishi, Y; Ikebuchi, K; Takahashi, TA; Katoh, T; Sekiguchi, S; Takazawa, M; Tanaka, H; Ikuta, K
  • Epidemiology of Borna disease virus
    Staeheli, P; Sauder, C; Hausmann, J; Ehrensperger, F; Schwemmle, M
  • Seroprevalence of Borna disease virus in domestic animals in Xinjiang, China
    Hagiwara, K; Asakawa, M; Liao, L; Jiang, W; Yan, S; Chai, J; Oku, Y; Ikuta, K; Ito, M

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