Evidence for genetic variation of Eurasian avian influenza viruses of subtype H15: the first report of an H15N7 virus

Evidence for genetic variation of Eurasian avian influenza viruses of subtype H15: the first... Since the first detection of H15 avian influenza viruses (AIVs) in Australia in 1979, only seven H15 strains have been reported. A new H15 AIV was detected in Ukraine in 2010, carrying the unique HA-NA subtype combination H15N7. This virus replicated efficiently in chicken eggs, and antisera against it reacted strongly with the homologous antigen, but with lower titers when using the reference Australian antigen. The amino acid motifs of the HA cleavage site and receptor-binding site were different from those in the Australian viruses. The new virus, together with an H15 virus from Siberia from 2008, constitutes a new clade of H15 AIV isolates. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Evidence for genetic variation of Eurasian avian influenza viruses of subtype H15: the first report of an H15N7 virus

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Publisher
Springer Vienna
Copyright
Copyright © 2016 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2629-2
Publisher site
See Article on Publisher Site

Abstract

Since the first detection of H15 avian influenza viruses (AIVs) in Australia in 1979, only seven H15 strains have been reported. A new H15 AIV was detected in Ukraine in 2010, carrying the unique HA-NA subtype combination H15N7. This virus replicated efficiently in chicken eggs, and antisera against it reacted strongly with the homologous antigen, but with lower titers when using the reference Australian antigen. The amino acid motifs of the HA cleavage site and receptor-binding site were different from those in the Australian viruses. The new virus, together with an H15 virus from Siberia from 2008, constitutes a new clade of H15 AIV isolates.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2016

References

  • Rapid molecular subtyping by reverse transcription polymerase chain reaction of the neuraminidase gene of influenza A viruses
    Fereidouni, SR; Starick, E; Grund, C; Globig, A; Mettenleiter, TC; Beer, M; Harder, T
  • Universal primer set for the full-length amplification of all influenza A viruses
    Hoffmann, E; Stech, J; Guan, Y; Webster, RG; Perez, DR
  • Genetic subtyping of influenza A viruses using RT-PCR with a single set of primers based on conserved sequences within the HA2 coding region
    Phipps, LP; Essen, SC; Brown, IH

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