Short Communications Incorporating Mouse Genome Mammalian Genome 9, 903–904 (1998). © Springer-Verlag New York Inc. 1998 Evidence against altered forms of MAG in the dysmyelinated mouse mutant claw paw 1 2 1 Stephan Niemann, Richard L. Sidman, Klaus-Armin Nave Zentrum fu ¨ r Molekulare Biologie (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772-9102, USA Received: 19 November 1997 / Accepted: 10 July 1998 In the mammalian nervous system, the formation of myelin by In an attempt to demonstrate the function of MAG in vivo, a glial cells enables a rapid saltatory impulse conduction. Myelina- null allele of the Mag gene has been created by gene targeting tion depends on the coordinated expression of myelin-specific (Montag et al. 1994; Li et al. 1994). Surprisingly, MAG-deficient structural proteins, based on interactions of axons with oligoden- mouse mutants displayed no obvious developmental defects, ex- drocytes in the central nervous system (CNS) and Schwann cells in cept for subtle ultrastructural abnormalities of myelin, in marked the peripheral nervous system (PNS). Mice with defects in myelin contrast to the dysmyelinated phenotype of claw paw, which is assembly comprise a
Mammalian Genome – Springer Journals
Published: Nov 1, 1998
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