Event-related potentials reflect impaired temporal interval learning following haloperidol administration

Event-related potentials reflect impaired temporal interval learning following haloperidol... Psychopharmacology (2017) 234:2545–2562 DOI 10.1007/s00213-017-4645-2 ORIGINAL INVESTIGATION Event-related potentials reflect impaired temporal interval learning following haloperidol administration 1,2,3 1,4 4 2,3 Sarah E. Forster & Patrick Zirnheld & Anantha Shekhar & Stuart R. Steinhauer & 1,4 1,4 Brian F. O’Donnell & William P. Hetrick Received: 17 December 2016 /Accepted: 10 May 2017 /Published online: 10 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract and correlations between ERP measures and behavioral indi- Background Signals carried by the mesencephalic dopamine ces of learning, overall accuracy, and post-error compensatory system and conveyed to anterior cingulate cortex are critically behavior were evaluated. We hypothesized that haloperidol implicated in probabilistic reward learning and performance would reduce ERN and FRN, but that ERN would uniquely monitoring. A common evaluative mechanism purportedly track automatic, error-related performance adjustments, while subserves both functions, giving rise to homologous medial FRN would be associated with learning and overall accuracy. frontal negativities in feedback- and response-locked event- Results As predicted, ERN was reduced by haloperidol and in related brain potentials (the feedback-related negativity (FRN) those exhibiting less adaptive post-error performance; howev- and the error-related negativity (ERN), respectively), er, these effects were limited to ERNs following fast timing reflecting dopamine-dependent prediction error signals http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Event-related potentials reflect impaired temporal interval learning following haloperidol administration

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
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