Event-related potentials reflect impaired temporal interval learning following haloperidol administration

Event-related potentials reflect impaired temporal interval learning following haloperidol... Psychopharmacology (2017) 234:2545–2562 DOI 10.1007/s00213-017-4645-2 ORIGINAL INVESTIGATION Event-related potentials reflect impaired temporal interval learning following haloperidol administration 1,2,3 1,4 4 2,3 Sarah E. Forster & Patrick Zirnheld & Anantha Shekhar & Stuart R. Steinhauer & 1,4 1,4 Brian F. O’Donnell & William P. Hetrick Received: 17 December 2016 /Accepted: 10 May 2017 /Published online: 10 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract and correlations between ERP measures and behavioral indi- Background Signals carried by the mesencephalic dopamine ces of learning, overall accuracy, and post-error compensatory system and conveyed to anterior cingulate cortex are critically behavior were evaluated. We hypothesized that haloperidol implicated in probabilistic reward learning and performance would reduce ERN and FRN, but that ERN would uniquely monitoring. A common evaluative mechanism purportedly track automatic, error-related performance adjustments, while subserves both functions, giving rise to homologous medial FRN would be associated with learning and overall accuracy. frontal negativities in feedback- and response-locked event- Results As predicted, ERN was reduced by haloperidol and in related brain potentials (the feedback-related negativity (FRN) those exhibiting less adaptive post-error performance; howev- and the error-related negativity (ERN), respectively), er, these effects were limited to ERNs following fast timing reflecting dopamine-dependent prediction error signals http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Event-related potentials reflect impaired temporal interval learning following haloperidol administration

Loading next page...
 
/lp/springer_journal/event-related-potentials-reflect-impaired-temporal-interval-learning-vm86n5utiW
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4645-2
Publisher site
See Article on Publisher Site

Abstract

Psychopharmacology (2017) 234:2545–2562 DOI 10.1007/s00213-017-4645-2 ORIGINAL INVESTIGATION Event-related potentials reflect impaired temporal interval learning following haloperidol administration 1,2,3 1,4 4 2,3 Sarah E. Forster & Patrick Zirnheld & Anantha Shekhar & Stuart R. Steinhauer & 1,4 1,4 Brian F. O’Donnell & William P. Hetrick Received: 17 December 2016 /Accepted: 10 May 2017 /Published online: 10 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract and correlations between ERP measures and behavioral indi- Background Signals carried by the mesencephalic dopamine ces of learning, overall accuracy, and post-error compensatory system and conveyed to anterior cingulate cortex are critically behavior were evaluated. We hypothesized that haloperidol implicated in probabilistic reward learning and performance would reduce ERN and FRN, but that ERN would uniquely monitoring. A common evaluative mechanism purportedly track automatic, error-related performance adjustments, while subserves both functions, giving rise to homologous medial FRN would be associated with learning and overall accuracy. frontal negativities in feedback- and response-locked event- Results As predicted, ERN was reduced by haloperidol and in related brain potentials (the feedback-related negativity (FRN) those exhibiting less adaptive post-error performance; howev- and the error-related negativity (ERN), respectively), er, these effects were limited to ERNs following fast timing reflecting dopamine-dependent prediction error signals

Journal

PsychopharmacologySpringer Journals

Published: Jun 10, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off