Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Veloso, V. Rodrigues, A. Azevedo, C. Oliveira, L. Gomides, L. Duarte, I. Duarte, A. Klein, A. Perez (2014)
Antinociceptive effects of Maytenus imbricata Mart. ex. Reissek (Celastraceae) root extract and its tingenone constituentJournal of Medicinal Plants Research, 8
K. Carvalho, T. Melo, Karina Melo, A. Quinderé, Francisca Oliveira, A. Viana, P. Nunes, J. Quetz, D. Viana, Armenio Silva, A. Havt, Said Fonseca, M. Chaves, V. Rao, F. Santos (2016)
Amyrins from Protium heptaphyllum Reduce High-Fat Diet-Induced Obesity in Mice via Modulation of Enzymatic, Hormonal And Inflammatory ResponsesPlanta Medica, 83
D. Schuster (2010)
Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammationDiabetes, metabolic syndrome and obesity : targets and therapy, 3
C. Schmidt, R. Murillo, T. Bruhn, G. Bringmann, M. Goettert, B. Heinzmann, V. Brecht, S. Laufer, I. Merfort (2010)
Catechin derivatives from Parapiptadenia rigida with in vitro wound-healing properties.Journal of natural products, 73 12
Lei Zhou, Yixing Li, T. Xia, S. Feng, Xiaodong Chen, Zaiqing Yang (2006)
Resistin overexpression impaired glucose tolerance in hepatocytes.European cytokine network, 17 3
Huaming Sheng, Hongbin Sun (2011)
Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases.Natural product reports, 28 3
M. Oliveira, Zélia Menezes-Garcia, M. Henriques, F. Soriani, V. Pinho, A. Faria, A. Santiago, D. Cara, D. Souza, Mauro Teixeira, A. Ferreira (2013)
Acute and sustained inflammation and metabolic dysfunction induced by high refined carbohydrate‐containing diet in miceObesity, 21
A. Casaschi, Brent Rubio, Geoffrey Maiyoh, A. Theriault (2004)
Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion.Atherosclerosis, 176 2
M. Yoshikawa, H. Shimoda, N. Nishida, M. Takada, H. Matsuda (2002)
Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats.The Journal of nutrition, 132 7
P. Agrawal (1989)
Carbon-13 NMR of flavonoids
David Jacobi, Kristopher Stanya, Chih‐Hao Lee (2012)
Adipose tissue signaling by nuclear receptors in metabolic complications of obesityAdipocyte, 1
S. Hasani-Ranjbar, Neda Nayebi, B. Larijani, M. Abdollahi (2009)
A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity.World journal of gastroenterology, 15 25
C. Steppan, S. Bailey, Savitha Bhat, Elizabeth Brown, Ronadip Banerjee, C. Wright, H. Patel, R. Ahima, M. Lazar (2001)
The hormone resistin links obesity to diabetesNature, 409
H. Satoh, M. Nguyen, P. Miles, T. Imamura, I. Usui, J. Olefsky (2004)
Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats.The Journal of clinical investigation, 114 2
J. Olefsky, C. Glass (2010)
Macrophages, inflammation, and insulin resistance.Annual review of physiology, 72
J. Choi, Yun-Hyeok Choi, Jeong-Min Lee, Ill Noh, J. Park, W. Choi, J. Choi (2012)
Anti-inflammatory effects of β-sitosterol-β-D-glucoside from Trachelospermum jasminoides (Apocynaceae) in lipopolysaccharide-stimulated RAW 264.7 murine macrophagesNatural Product Research, 26
M. Valerio, A. Awad (2011)
[beta]‐Sitosterol (SIT) down‐regulates some pro‐inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase SHP‐1 in J774A.1 murine macrophagesThe FASEB Journal, 25
S. Pinto, L. Pinto, Geanne Cunha, Mariana Chaves, Flávia Santos, V. Rao (2008)
Anti-inflammatory effect of α, β-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitisInflammopharmacology, 16
NT Dat, NP Thao, LTP Quynh, CV Minh, TT Bach, LJ Joon (2009)
Flavonoids from Eupatorium odoratum as inhibitors of NF-KBJUST, 47
P. Chantre, D. Lairon (2002)
Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity.Phytomedicine : international journal of phytotherapy and phytopharmacology, 9 1
K. Shankar, Amanda Harrell, Ping Kang, Rohit Singhal, M. Ronis, T. Badger (2010)
Carbohydrate-responsive gene expression in the adipose tissue of rats.Endocrinology, 151 1
C. Moro, G. Basile (2000)
Obesity and medicinal plants.Fitoterapia, 71 Suppl 1
L. Engstrom, L. Bober, Shu‐Cheng Chen, J. Fine, Ying Li, Michaela Stanton, David Kinsley, Long Cui, J. Jackson, A. Rojas-Triana, D. Lundell, M. Laverty, E. Gustafson, C. Jenh, T. Kowalski, D. Manfra (2010)
Kinetic Assessment and Therapeutic Modulation of Metabolic and Inflammatory Profiles in Mice on a High-Fat and Cholesterol DietPPAR Research, 2010
V. Oliveira, A. Ferreira, M. Oliveira, M. Teixeira, M. Brandão (2014)
Effects of Xylopia aromatica (Lam.) Mart. fruit on metabolic and inflammatory dysfunction induced by high refined carbohydrate-containing-diet in miceFood Research International, 62
A. Ferreira, E. Mario, L. Porto, S. Andrade, L. Botion (2011)
High-Carbohydrate Diet Selectively Induces Tumor Necrosis Factor-α Production in Mice LiverInflammation, 34
A. González-Périz, J. Clària (2010)
Resolution of Adipose Tissue InflammationThe Scientific World Journal, 10
A. Yadav, M. Kataria, V. Saini, A. Yadav (2013)
Role of leptin and adiponectin in insulin resistance.Clinica chimica acta; international journal of clinical chemistry, 417
V. Rodrigues, L. Duarte, G. Silva, F. Silva, Jefferson Góes, J. Takahashi, L. Pimenta, S. Filho (2012)
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricataQuímica Nova, 35
C. Maffeis, D. Silvagni, R. Bonadonna, A. Grezzani, C. Banzato, L. Tató (2007)
Fat cell size, insulin sensitivity, and inflammation in obese children.The Journal of pediatrics, 151 6
A. Guilherme, J. Virbasius, V. Puri, M. Czech (2008)
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetesNature Reviews Molecular Cell Biology, 9
T. Matsusaka, K. Fujikawa, Y. Nishio, N. Mukaida, K. Matsushima, T. Kishimoto, S. Akira (1993)
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.Proceedings of the National Academy of Sciences of the United States of America, 90 21
M Valerio, AB Awad (2011)
β-Sitosterol down-regulates some pro-inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase SHP-1 in J774A.1 murine macrophagesInt Immunopharmacol, 11
Si-yang Fan, H. Zeng, Y. Pei, Li Li, Ji Ye, Yue-Xin Pan, Jigang Zhang, X. Yuan, Wei-Dong Zhang (2012)
The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo.Journal of ethnopharmacology, 141 2
A. Lemhadri, M. Eddouks, T. Sulpice, R. Burcelin (2007)
Anti-hyperglycaemic and Anti-obesity Effects of Capparis spinosa and Chamaemelum nobile Aqueous Extracts in HFD MiceAmerican Journal of Pharmacology and Toxicology, 2
Haiyan Xu, Glenn Barnes, Qing Yang, G. Tan, Daseng Yang, C. Chou, Jason Sole, A. Nichols, J. Ross, L. Tartaglia, Hong Chen (2003)
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.The Journal of clinical investigation, 112 12
A. Chawla, K. Nguyen, Y. Goh (2011)
Macrophage-mediated inflammation in metabolic diseaseNature Reviews Immunology, 11
R. Lamb, B. Goldstein (2008)
Modulating an oxidative-inflammatory cascade: potential new treatment strategy for improving glucose metabolism, insulin resistance, and vascular functionInternational Journal of Clinical Practice, 62
Niti Sharma, V. Sharma, S. Seo (2005)
Screening of some medicinal plants for anti-lipase activity.Journal of ethnopharmacology, 97 3
R. Cañete, M. Gil-Campos, C. Aguilera, Á. Gil (2007)
Development of insulin resistance and its relation to diet in the obese childEuropean Journal of Nutrition, 46
C. Veloso, Marina Oliveira, C. Oliveira, V. Rodrigues, A. Giusti-Paiva, Mauro Teixeira, I. Duarte, A. Ferreira, A. Perez (2014)
Hydroethanolic extract of Pyrostegia venusta (Ker Gawl.) Miers flowers improves inflammatory and metabolic dysfunction induced by high-refined carbohydrate diet.Journal of ethnopharmacology, 151 1
The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural products derived from plants have an important role in the prevention and treatment of obesity. Accordingly, we evaluated the effect of Maytenus imbricata extracts in the treatment of obesity induced by diet rich in refined carbohydrate (HC). BALB/c mice were fed chow or HC diet for 8 weeks. At the beginning of the 9th week, the HC group was subdivided into three groups: (i) group of animals that continued to consume only HC diet; (ii) the group of animals fed HC diet supplemented with ethyl acetate extract of M. imbricata roots (HC + EAE); (iii) the group of animals fed HC diet supplemented with extract in hexane/ethyl ether (HC + HEE). The period of extracts supplementation was 4 weeks. It was observed that EAE and EHE when added to the HC diet modulated the metabolic and inflammatory changes, such as: reduced the adipocytes area, improved glucose intolerance, reduced the levels of triglycerides and resistin in serum, and the number of total leukocytes in blood. In the epididymal adipose tissue, the extracts reduced proinflammatory mediators’ concentration. According to the results, it was concluded that the species Maytenus imbricata has the potential to be used for the treatment of obesity.
Inflammopharmacology – Springer Journals
Published: May 31, 2018
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.