Objectives To evaluate right ventricle (RV) function by coronary computed tomography angiography (CTA) using a novel automated three-dimensional (3D) RV volume segmentation tool in comparison with clinical reference modalities. Methods Twenty-six patients with severe end-stage heart failure [left ventricle (LV) ejection fraction (EF) <35%] referred to CTA were enrolled. A specific individually tailored biphasic contrast agent injection protocol was designed (80%/20% high/low flow) was designed. Measurement of RV function [EF, end-diastolic volume (EDV), end-systolic volume (ESV)] by CTA was com- pared with tricuspid annular plane systolic excursion (TAPSE) by transthoracic echocardiography (TTE) and right heart invasive catheterisation (IC). Results Automated 3D RV volume segmentation was successful in 26 (100%) patients. Read-out time was 3 min 33 s (range, 1 min 50s–4 min 33s). RV EF by CTA was stronger correlated with right atrial pressure (RAP) by IC (r =-0.595; p = 0.006) but weaker with TAPSE (r =0.366, p = 0.94). When comparing TAPSE with RAP by IC (r =-0.317, p = 0.231), a weak-to-moderate non-significant inverse correlation was found. Interobserver correlation was high with r =0.96 (p <0.001), r =0.86 (p <0.001) and r =0.72 (p = 0.001) for RV EDV, ESVand EF, respectively. CT attenuation of the
European Radiology – Springer Journals
Published: Jun 4, 2018
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