Mammalian Genome 9, 385-387 (1998). Mammalian Genome Incorporating Moose Genome © Springer-Verlag New York Inc. 1998 Evaluation of mouse Sfrp3/Frzbl as a candidate for the 1st, Ul, and Far mutants on Chromosome 2 Catherine L. Peichel,' Christine A. Kozak, 2 Frank P. Luyten, 3'* Thomas F. Vogt' 'Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA 'Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland 20892, USA 3 Craniofacial and Skeletal Diseases Branch, NIDR, NIH, Bethesda, Maryland 20892, USA Received: 30 September 1997 / Accepted: 19 December 1997 Members of the Wnt family of secreted signaling molecules play mouse Chr 2: 1st (Strong's luxoid; Vogt and Leder 1996) and Ul important roles in many biological processes, including vertebrate (Ulnaless; Peichel et al. 1996) have limb defects, and Far (First limb development (Parr and McMahon 1994, 1995). Although arch; Dreger et al. 1995) has craniofacial defects. many of the components of Wnt signaling pathways are known, the Lst is a semidominant mutation leading to preaxial polydactyly identity of an Wnt extracellular receptor has remained elusive until in the hindlimbs of heterozygotes. In homozygotes, there is more recently. Genes of the frizzled family have been isolated and
Mammalian Genome – Springer Journals
Published: Mar 27, 2009
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